Weighted Squats hit the anaerobic, glycogen system, hard.
Once a week, I do a long, slow jog of about five or six miles at an aerobic pace. At no point am I gassed.
Also, once a week, I do a five set squat routine: 20, 15x2, 12x2. By the end of the forth set, my mind is looking for excuses to not do the fifth. At the end of the fifth set, I'm completely blow up.
That said, squats won't help you with running. No matter how much you squat, if you don't run, you'll be gassed by 1/4 mile.