here's the gist of it...
So, how much gear can the body actually use? We cannot say for certain, as there are several factors which can impact an individual’s ability to use AAS, but science has still provided us with a ballpark figure. According to medical research, the average human being will reach the point of receptor saturation at about 3,500 mg per week. That means at 3,500 mg per week, every single available androgen receptor site will be filled up! While AAS are also capable of inducing a growth response through non-genomic mechanisms (non-AR mediated muscle growth), AR activation is the primary mechanism through which steroids stimulate muscle protein synthesis. We do know that AAS themselves are capable of directly increasing AR count, so it is very likely this number will rise at least slightly beyond 3,500 mg in heavy steroid users, but we do not know exactly how much. In situations like this, the best we can do when attempting to come to a conclusion is to evaluate the available anecdotal evidence in light of scientific fact. Often, this will help us to fill in the blanks…and in this case we have more than enough anecdotal evidence to draw from.
Based on the personal response of BB’rs over the last 15 or so years (since the mega-dosing started in earnest), it appears that most BB’rs reach the point of diminishing returns somewhere between 3.5-5 grams per week. Among those BB’rs who do appear to receive additional benefit by increasing their dose to the 5 gram per week mark, most will readily confess that their gains barely improved by adding that extra 1,500 mg….and many BB’rs will notice no improvement in growth rate at all. Therefore, real-world experience appears to confirm what science has been telling us for years; that 3,500 mg per week is about the limit for the average person. Personally, I have never known a single BB’r who claims to have experienced measurably better gains when using 7, 8, 9 or more grams of gear per week than when using a more modest, but still massive dose of 3-5 grams weekly.
http://www.ironmagazine.com/2013/13-grams-of-anabolic-steroids-per-week/
