I see you wrote about a female drinking a lot.
That became a dealbreaker for one of my long-term relationships. When we first started dating, she lived quite far from me, but her family and their business was in my city. I would visit her, we would go out to dinner, she would drink what I thought was to excess, but I thought it was just because it was the weekend, we weren't driving, etc.
We get serious, and I realize that she drinks way more than anyone should, quite often. And is taking anti-depressants. Sad, really. She had a ton of potential, but didn't want to listen to anyone's sound advice. I heard she got into AA and is sober now.