I still haven't tried psychedelics. Simply because I'm afraid it might send me to hell for 12 hours 
Some people I listen to have recommended taking a "heroic dose" of shrooms and sitting in a dark room by yourself as the best way. These guys say it's possibly life changing in a positive sense. How would you go about it if it was your first time?
Anyone else? Spike?
DMT you need someone there to guide you. There are Shaman that specialize in helping you. Come to New Mexico and i'll hook you up.
DMT can literally send you to hell. I've only done it twice and it was an amazing experience. Imagine experiencing your entire life from a 3rd point of view. It's wild and will make you change things about yourself.
With LSD or shrooms, you want someone there who has done it before to watch after you. The first trip can make people a little wild and do stupid things. My first few trips were with friends.
You want to be somewhere safe and where you will not be bothered. Do not do them in public or in a place where sober people will randomly appear. Be alone in a house, nice and dark. Or maybe out in the woods. But beware things are going to look and feel different. Everyone responds a little different to their first trip.
After a few trips you can do it anywhere. We used to go to my friends ranch in Texas and drive around on 4-wheelers all night. Look at the stars. Start a fire and just chill.
Don't do anything dangerous and do not try to drive a car. Your motor skills will be fine, but your timeframe of existence will be distorted. You might think it's been 3 minutes and it's been 30.
Stay hydrated and be with people who care about you. It can be an emotional experience. But generally, you will see things differently and feel things WAY differently. Go roll around in the grass like a dog for 30 minutes. Fall in love with a music album from years passed. It can be different for everyone.
Some people like myself have seen things, weird things. People morph into animals and walls disappear. I watched my friend turn into Marilyn Manson and it was as real as anything. Was at an apartment and could see through the walls to the outside area with perfect precision. Weird shit.
Walked out side my friends house during the day and everything looked like a cartoon, like in that Roger Rabbit movie. It was wild.
It is very fun, but some people can have a bad trip. You need to be in a good place mentally and with good people.