Interesting comparison between very small caliper ammunition (.22 Magnum vs .22LR):
(For the ones living under very restrictive gun laws like myself)
Damaging power from minute 8:50 on.
Either one of those will do the job.
A couple observations.
One is that the kick from the .22LR is much less than the .22 Magnum round.
.22LR is much easier to keep on target even if shooting one handed.
Small .22 handguns (smaller than those in the video) are very easy to conceal and carry. You can just put one in your pocket while making a stop at the convenience store.
Larger handguns are cumbersome, uncomfortable, and hard to conceal, which may cause you to not want to carry them around, and if you don't have it with you it won't help you.