Peptide thread

[Grape Ape]

As stated, I tore my hamstring a bit on 8/22 and was considering peptides to see if it would help accelerate healing.

For no reason, I'll share results here just to do it, although nobody will likely find this subforum, let alone this thread.

Hamstring showed some bruising/blood collection, so it was likely a small tear.  I have had 3 PT sessions focusing on utlrasound and muscle scraping.  After nine days, I feel no pain when performing walking and regular activities, but I can at times "feel it" - no pain, but it's there.

However, if I press into it there is slight pain today.  Likely because last PT session they had me do 2 sets of 10 reps on just the eccentric part of a hamstring curl - first was no weight, second was 10lbs.......no pain, but again, could just feel it was there on the second set.

Anyway, bought 5mg of BPC-157 / 5mg TB-500 from Biotech Peptides and another 10mg of BPC 157 for Peptide Sciences.  Both seemed reputable from research.

Today was a shot of 2.5 mg of BPC and TB straight into the injury site.  Was only using an insulin needle so it likely didn't go in too deep.  There are different arguments of whether injury site injection matters, or if it doesn't and you can just sub-q inject in your belly or wherever (or if it even works at all).

Plan is then to inject .5mg of BPC daily until I run out, except in 3 days to repeat today's shot.

Will see if pain changes in next two days.

Also, never injected, so this feels fucking weird.

I don't think I could ever do steroids lol

[IroNat]

I missed your previous report.
How did you tear it?

[falco]

TB500 did wonders for my rotator cuff partial tear.

[Grape Ape]

I missed your previous report.
How did you tear it?

Baseball.

Had to full out sprint on first play of the game.

Did legs the night before, was sore, probably didn't warm up enough.

My fault.

[Grape Ape]

Have done two subsequent .5mg BPC injections since first injection.  Will likely shoot the remainder 2.5mg and 2.5bpc mix in the next day or two, then 8 more days of .5 bpc

Not sure if placebo, timing of use, or if it actually works but it DOES feel much better.

Was able to do about 9 sets of eccentric movements, and it felt worlds better than 3 days ago when we introduced this.

I am also able to lightly jog.

Dry needling likely next week.

[Grape Ape]

PT decided against dry needling, and have suggest I start a "return to sprint" program instead.

Today was just running at 50% a couple of times for 50 yards.

If no pain tomorrow, do it again, a bit more effort.

Injected 1.0 mg of BPC - have been doing maintenance of .5, but getting sick of the injections and will double dose until I run out.

[Grape Ape]

Updating thread nobody will read.

I was able to return to baseball on Tues, but played it safe and took a pinch runner anytime I reached base, and did not play defense.

Only scare was when instinct took over and I accidently ran hard.  No ill effects though.

I will play tomorrow in the field.

I've been encouraged by how fast the progress has been.  I ordered another round of peptides, since these injuries don't fully heal until 6-8 weeks, I believe.  It's been 4.

[deadz]

I've used BPC on my elbows and knees, works well.

[illuminati]

Updating thread nobody will read.

I was able to return to baseball on Tues, but played it safe and took a pinch runner anytime I reached base, and did not play defense.

Only scare was when instinct took over and I accidently ran hard.  No ill effects though.

I will play tomorrow in the field.

I've been encouraged by how fast the progress has been.  I ordered another round of peptides, since these injuries don't fully heal until 6-8 weeks, I believe.  It's been 4.

Interest feed back - you believe its helping you to heal quicker ?

[Grape Ape]

Interest feed back - you believe its helping you to heal quicker ?

It's hard to tell, but if pressed, I'd have to say yes.

I had a real tear - bruising, discoloration, limping.

I did go hard - PT twice a week, eccentric training, ultrasound, fascia scraping, etc.........

But after four weeks I was playing again...probably able to full sprint this week.  Hamstrings are usually a 4-6 week thing, but at age 56 to recover like this, I'm going with a yes.

[IroNat]

Baseball is my favorite team sport.
Played a lot when young.
I watch a lot of baseball now.

[illuminati]

It's hard to tell, but if pressed, I'd have to say yes.

I had a real tear - bruising, discoloration, limping.

I did go hard - PT twice a week, eccentric training, ultrasound, fascia scraping, etc.........

But after four weeks I was playing again...probably able to full sprint this week.  Hamstrings are usually a 4-6 week thing, but at age 56 to recover like this, I'm going with a yes.

Sounds good - glad they helped you.

Yep as we age healing & recovery slow down worse luck.

[Grape Ape]

Sounds good - glad they helped you.

Yep as we age healing & recovery slow down worse luck.

Peptides could be the next big thing here.  I think it's legit because big pharma is, on one hand, downplaying peptides publicly, while on the other hand, trying to get patents on them.

[Necrosis]

Peptides are the next big thing. I have heavily into them and do a ton of research with them.

The new mitochondrial peptides have a chance to be incredibly useful for disease across the board.

There are some ergogenic benefits as well.

KLOW blend would be best for a tear or injury site in my opinion. you could even add in a GHRH or GHRP to help with healing. The klow blend works so well though.

[Necrosis]

While there is no chance of this getting bumped down as so few post here I am going to sticky this topic as I will post various peptides and there uses and research as I think this is a great topic.

Peptides can make a huge difference.

[Grape Ape]

Peptides are the next big thing. I have heavily into them and do a ton of research with them.

The new mitochondrial peptides have a chance to be incredibly useful for disease across the board.

There are some ergogenic benefits as well.

KLOW blend would be best for a tear or injury site in my opinion. you could even add in a GHRH or GHRP to help with healing. The klow blend works so well though.

I was going to try GLOW. Thanks for pointing out KLOW, I hadn't heard of that one.

I'm on a real good injury kick lately.

Literally running easy on a double three weeks ago and sprained my foot. Doing nothing.

Since I've had four tendon  / muscle injuries this year, I went to my primary to see if she thought my statin doses could be weaking my tendons/muscles.....she didn't think so.

Either way, I was going to try this:

Glow:

https://www.peptidesciences.com/bpc-157-tb-500-ghk-cu-glow-blend?size=30mg

Klow:

https://www.peptidesciences.com/bpc-157-tb-500-kpv-ghk-cu-80mg-klow-blend

The issue I have with these is the dosage - hard to figure out what's right.  KLOW is interesting, but more than double the price.

[Necrosis]

I was going to try GLOW. Thanks for pointing out KLOW, I hadn't heard of that one.

I'm on a real good injury kick lately.

Literally running easy on a double three weeks ago and sprained my foot. Doing nothing.

Since I've had four tendon  / muscle injuries this year, I went to my primary to see if she thought my statin doses could be weaking my tendons/muscles.....she didn't think so.

Either way, I was going to try this:

Glow:

https://www.peptidesciences.com/bpc-157-tb-500-ghk-cu-glow-blend?size=30mg

Klow:

https://www.peptidesciences.com/bpc-157-tb-500-kpv-ghk-cu-80mg-klow-blend

The issue I have with these is the dosage - hard to figure out what's right.  KLOW is interesting, but more than double the price.

Thats really odd that its that much more tbh. Up here its like 20 bucks more at most, the only difference is KPV which is a very good anti-inflammatory and healing peptide.

I would do 10-12 units a day with this dosing.

[falco]

Peptides are the next big thing. I have heavily into them and do a ton of research with them.

The new mitochondrial peptides have a chance to be incredibly useful for disease across the board.

There are some ergogenic benefits as well.

KLOW blend would be best for a tear or injury site in my opinion. you could even add in a GHRH or GHRP to help with healing. The klow blend works so well though.

When i lay down over my right shoulder, it feels like i have loose rocks inside it. That is bone on bone due to wear. TB500 helped me a lot regenerating those lost tissues. And it's inexpensive.

[Grape Ape]

Thats really odd that its that much more tbh. Up here its like 20 bucks more at most, the only difference is KPV which is a very good anti-inflammatory and healing peptide.

I would do 10-12 units a day with this dosing.

Thank you - do you have a reputable source or link to order from?

[Necrosis]

Thank you - do you have a reputable source or link to order from?

Only in canada, not sure if that will help you are not. Peptidepro.net is a good spot. cheap and lab certified.

[Necrosis]

i will start posting more info about different peptides as there is a shit ton out there now

Mots-c is one of my favorite peps.

Essentially it peptide released from the mitochondria and appears to induce mitochondrial biogenesis and reduce stress on the mitochondria improving energy metabolism. It enhances insulin sensitivity and fat loss via AMPK (think metformin) which is a master switch for metabolic partitioning and signalling. It improves muscle function and endurance and there is some evidence is inhibits myostatin, the gene that regulates muscle growth.

I have noted substantially increases in energy levels, recovery from workouts and fullness from taking this. I am a metric nut so I do not blood glucose, ketones etc when taking stuff as this consistently improves glucose clearance. The energy levels are noteworthy, I simply can do more without getting tired and this is reflected in HRV and heart rate while doing endurance work. Taking this with reta, the fat just falls off you.

Only caveats are that it can cause injection site reactions and I have noted insomnia from higher dosages.

[Necrosis]

SELANK

This bioactive compound is derived from tuftsin, an immunomodulatory peptide. This peptide was originally isolated from blood serum and has since been the subject of extensive research due to its immunomodulatory properties.

Researchers discovered that tuftsin played a pivotal role in regulating immune functions, promoting the phagocytic activity of macrophages, and influencing various aspects of the immune response.

Selank, however, represents a refined and synthetic variation of tuftsin. It was meticulously designed to capitalize on the therapeutic potential of its parent peptide while addressing concerns about stability and potential side effects. Selank is a smaller and more stable peptide, composed of just seven amino acids, making it an ideal candidate for therapeutic applications.

Selank method of action

- selank increases brain derived neutrophic factor (bdnf) which increase plasticity and dendritic connections between neurons. This has the effect of improving memory, learning and overall cognition with some benefits for PTSD in terms of remapping.

- selank is a allosteric modulator of the gabaA receptor, this is the major inhibitory neurotransmitter in the human body and the overall effect of this is anxiolysis, mild sedation and stress reduction. It does not appear to effect gabaB which is more so a muscular related receptor. It increases the expression of genes associated with GABA as well

- It may increase dopamine receptor sensitivity along with upregulating tyrosine hydroylase which increases catecholamine production

- it decreases levels of IL-6 which is a myokine and tnfa which is pro-inflammatory mediator. This action may reduce microglia and result in improved mood along with a possible reduction in neurodegenerative conditions.

- It appears to increase serotonin through the mechanisms above.

- In the literature there is no tolerance or dependence like classical gabaergics like the benzos or barbs.

[Grape Ape]

Great stuff necrosis.

Super interesting to read.

So, I have come to the conclusion that injecting at site of injury is just broscience.  I could be wrong though.

Do you just inject in the stomach area?

[Necrosis]

Great stuff necrosis.

Super interesting to read.

So, I have come to the conclusion that injecting at site of injury is just broscience.  I could be wrong though.

Do you just inject in the stomach area?

Thanks. I will post a bunch more as this shit is pretty cool and I can nerd out on it.

That appears to be correct as there isn't really any literature on it, just inject into the gut and it should migrate when needed.

I have never used BPC-157 but a bunch of other peptides, always in the gut unless you need to rotate for injection site irritation.

[Necrosis]

The incretins in a nutshell.

Semaglutide, tirz and reta- there are others and some very cool ones in the pipeline like bioglutide.

Sema

- glp1 receptor agonist- very similar to human glp1 and nearly equally as potent. Increases insulin sensitivity through a variety of mechanisms, reduces glucagon, slows gastric motility, reduces appetite. The nausea on this bad boy is the worst, because its agonizing one pathway heavily the side effects can be bad. This drug binds multiple receptors in the brain, namely in the area postrema which induces nausea and in the mesocorticolimibic pathway. It appears to impact reward signalling in the nucleus accumbens and quite frankly looks like a real winner for addiction as well. I believe it is the strongest anti-craving drug seen for alcohol so far- in the preliminary studies, but it extends to all addiction. Huge cardiovascular benefits, modest lipid impact. The effects down stream and ubiquitous.

Tirz

- glp1ra and GIP agonist- its a weaker glp than sema and the GIP works in synergy with the glp to enhance most of the benefits. The workings of GIP are pretty complex, some drugs increase it and reduce body weight, some reduce it and have the same effect, the impact is polyvalent. The extra glp benefits are less nausea as it is a mild anti-emetic and that is may improve triglyceride reduction. In our body it inhibits hormone sensitive lipase but may increase it with a glp but the data is mixed. Much better for weight loss

Reta

triple agonist, only novel mechanism is the glucagon agonism. Its about 8.9 times weaker as a glp then sema and the highest gip activity, so its easier on the guts in some ways. The glucagon action, reduces liver fat dramatically, increase basal metabolic rate, increases hormone sensitive lipase, increase hepatic ketone production, increase contractility and rate of the heart and depletes liver glycogen. The best for weight loss



Some musings. A recent paper highlighted that exogenous ketone supplementation, namely beta hydroxy butyrate made reduce incidence of sarcopenia from these drugs- they are not inherently sarcopenic and a recent study showed improved muscle function in type 2s. If someone were to be on reta and ingest ketones they may see higher levels of muscle retention and ketone production.