Peptides/ GH

[JK]

Placebo effect?

Not really. While using these peptides, I experienced terrible numbness in my hands and wrist pain, which I didn't expect at all.

[Griffith]

MK-677 isn't a peptide but for the sake of discussion let's include it. It will certainly make you fuller and most likely stronger and most get very, very hungry too. The fullness is from water retention and unfortunately plenty under the skin too.Just be wary of the insulin resistance and use a glucometer preferably. My solution is Toujeo long acting insulin and some Novorapid. Should be obvious injecting more insulin won't make you more sensitive, I think of it as a temporary protectant for the limited time you are on it.

There's one coaching clique who uses small doses of insulin before meals because they think you should be 90 or under glucose before digesting another carb heavy meal optimally. Some, I think Aceto is one, like to do a small dose say morning on an empty stomach before cardio because they believe burning off some glucose before the cardio will make the body tap into body fat easier. But insulin does stop fat burning too so there are disputes around this technique.

But almost all agree that insulin itself doesn't make you fat and you can get just as ripped with it vs without.

A little insulin resistance may help in liberating fat. The cell doesn't accept fat as easy. Think about it, very obese people lose fat at a crazy rate at the beginning of diet. Lyle McDonald said IR is a protective mechanism so we don't just get fatter and fatter.

Yes, he mentioned secretagogues.

I used basically non-stop for a year (with some short breaks in between) at 20mg and then for another year, and for several months at a time after that, and didn't use any insulin. Sometimes I did use Alpha Lipoic Acid but not sure if it made any difference.

If there was any insulin resistance I think it must have been temporary as I have no issues with extra fat or getting lean after stopping longer-term MK-677.

Perhaps it doesn't push HGH and IGF-1 to high enough levels? Maybe equivalent to 2 IU's at 20-25 mg doses? Though some studies I've read says it puts the levels at about those of a 18-20 year old, and it's of course still produced by the body and not exogenous.

[beakdoctor]

Appreciate all the feedback.

Ive used MK677 from different sources and results varied from source to source. But I guess that is to be somewhat expected. One person swears by this source and another person says their order was bunk. I see that quite a bit.

I didn't like the side effects at 25 MG doses. Water, constant craving for carbs, weight gain, BP, but worst was the total inertia. Lethargic is an understatement. It was great for sleep, which I struggle with, so that was a huge benefit.

Tried it at lower doses, 12 mgs or something like that and it wasn't effective. Just slightly improved sleep.

Another question on peptides: the tablet/pill form is basically useless correct?

I see so many companies selling tablet/pill forms. But they are not orally bioavailable is my understanding.

[Grape Ape]

Appreciate all the feedback.

Ive used MK677 from different sources and results varied from source to source. But I guess that is to be somewhat expected. One person swears by this source and another person says their order was bunk. I see that quite a bit.

I didn't like the side effects at 25 MG doses. Water, constant craving for carbs, weight gain, BP, but worst was the total inertia. Lethargic is an understatement. It was great for sleep, which I struggle with, so that was a huge benefit.

Tried it at lower doses, 12 mgs or something like that and it wasn't effective. Just slightly improved sleep.

Another question on peptides: the tablet/pill form is basically useless correct?

I see so many companies selling tablet/pill forms. But they are not orally bioavailable is my understanding.

I tried BPC-157 pills and it did bupkis.

Injectable was different, based on what I posted in the other thread.

Sourcing may also be important.

[nobody in particular]

we have public health care here in aus so I won't see the surgeon again unless something goes wrong(fingers crossed and all that).

A good friend of mine had serious shoulder pain that physios and even a well known local powerlifter just couldn't make a dent on. he is perhaps the most self aware person I have ever met, you wouldn't get a placebo past him in a milliom years. Anyway, the so called wolverine stack - tb500 and bpc157 turned that around and he's even considering a powerlifting meet or two (and he certainly has the genes for it and the mindset). For them to work for him I have to believe they at least work for some. His source is direct from china. Sadly that window is closing, thanks to the fentanyl and nitazine laced pharma stuff coming in, and resultant deaths) so he will have to locally source. that roughly triples the price but let the importing be somebody else's headfuck i guess.

[Van_Bilderass]

Another question on peptides: the tablet/pill form is basically useless correct?

I see so many companies selling tablet/pill forms. But they are not orally bioavailable is my understanding.

They may be bioavailable to one degree or another  My concern is handling of the peptide and the exact dosing when we are talking micrograms. It's not easy and I don't trust these repackaging companies. I would buy the lyophilized vials and just squirt into an empty gelcap each time. Feels logical to me