Ephedra was such a big money maker for supp companies I believe Twinlab went under because of the ban. I remember Muscular Development and Twinlab was lobbying against the upcoming ban, lots of articles contesting the supposed danger of ephedrine.
It was part of it. They had 4 big products that did great for them - the early andro products, the ephedra stuff, CoQ10, and shark cartilage. When those where booming, they had a stock offering that went from $12ish to $48 share fast. They borrowed a ton based on this new value.
From there, three big things happen - 1) Family infighting about the direction of the brand. One side wanted to stay sports and fitness, while the other wanted to generalize and go older. 2) Big drug companies started buying up supplement brands, and they had much better reach. 3) Andro and Ephedra started to really get looked at and cracked down on.
Twinlab wasn't able to stall anymore, and was bankrupt by 2003.