...i don't know if anyone else has come across something like this on the net/boards??? help please!!!!
"...There are three senarios for CEE (CE2):
1) CEE is a true covalently bonded ester and is absorbed into blood and
Tissues as the intact molecule. This is the picture that the
Manufacturers would have us believe and is the basis for why they claim
CEE is superior to Creatine monohydrate. However, inside cells CEE
Will be unreactive with Creatine kinase and may be a potential
Competitive or non-competitive inhibitor to the enzyme. This would
Make it toxic to brain, heart, testes, muscle and all other CK
Containing tissues. People by now should be dying, but clearly are not
And this means 2) and 3) are the more likely. Nonethess, CEE should be
Treated as a potentially toxic phrarmaceutical and in the US should be
Treated as a drug, which requires multi species studies
To estimate LD50's and potential sites of tissue damage etc. However, recently I have
Been told that CEE did get new dietary ingredient status (scary).
2) CEE is hydrolysed to Creatine on absorption from the gut. In this
Case CEE offers no advantage over Creatine monohydrate which has a
Bioavilability of 100%. Indeed if hydrolysis of CEE is less than 100%
Then it will be inferior to the monohydate. But in the case of
Hydrolysis there are no circumstances in which it could be better than
The monohydrate in increasing tissue Creatine levels. Obviously CEE
Manufacturers would prefer 1) except that they then shoot themselves in
The foot over the issue of potential toxicity.
3) CEE is not a true covalently bonded ester. The whole of this is a scam
With the compound ionising in solution to free Creatine, as does the
Monohydrate and all salts of Creatine. In this case CEE would again
Represent no advantage over Creatine monohydrate, except to the seller
Who can double the price.
The failure of the US sports nutrition community (industry and the
Universities) to call for closer examination of CEE seriously questions its
Credibility in the eyes of many scientist in this country and the world. A simple water
Solvation test would answer 3), I.e. Whether or not it was a covalent
Or ionisable derivative of Creatine. The work time would be about one
Hour. Investigation of whether CEE is a competitive or non-competitive
Inhibitor of Creatine kinase would take 2-3 hours. If either of these
Occurred then clearly CEE must be investigated in at least two species
To investigate lethality and potential organ damage. If on the other
Hand CEE is ionisable then I see no reason why a bioavailability study
Should not be undertaken comparing this, on a molar/molar basis, with
Creatine monohydrate. My guess is that plasma AUC would be identical.
Again a very simple study.
None of this is rocket science but could spare a few lives, if the
Manufacturers claims on the absorption of CEE are to believed..."
