Author Topic: For ShiftedShapes, The MOST MUSCULAR MYOSTATIN Dog!!! "Arnold" of the DOG WORLD!  (Read 7878 times)

ieffinhatecardio

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That's the freakiest looking dog I've ever seen. It looks like some kind of lab experiment or cartoon character come to life. I wonder if all that muscle is functional or if it's so muscle bound that it has a hard time doing the typical activities normal to the Whippet breed.

shiftedShapes

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That's the freakiest looking dog I've ever seen. It looks like some kind of lab experiment or cartoon character come to life. I wonder if all that muscle is functional or if it's so muscle bound that it has a hard time doing the typical activities normal to the Whippet breed.

they are faster out of the blocks but lack the stamina for the normal distance 200m sprints I believe.  Also may lack the aggressive character, they tend to be very docile.

The True Adonis

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Including muscle huh?  I'd be interested in a link if you have one.  I'd also love to know how the Wyeth study on MYO-29 turned out.  They finished it a year ago and haven't released findings yet.  Drug development is sooooo slow, thank god The Singularity is Near.

The Belgian blues, and the mighty mice don't have shorter lifespans do they?  I'm curious as to why you and the authors of this article predict respiratory trouble for Wendy, is there data suggesting that it is a likely outcome?
http://www.detnews.com/apps/pbcs.dll/article?AID=/20070607/METRO/706070357/1003

This is current and is a different person than the German baby.

The True Adonis

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they are faster out of the blocks but lack the stamina for the normal distance 200m sprints I believe.  Also may lack the aggressive character, they tend to be very docile.
This should shed some light on what Wyeth is doing and a little on the German boy who is no longer stronger than normal:

Superbaby Serum
Matthew Herper 02.26.07


Related Quotes
WYE 57.35 - 0.13
 
 
 
A brawny infant's mutation has set off a hunt for a muscular dystrophy drug.
The child was the talk of the Neonatal Ward at Charite Hospital in Berlin, Germany. His biceps and and thighs were twice as thick as a normal newborn's despite typical height and weight. He looked like he'd been lifting weights in the womb.

This was in 2000. The child's doctor called in pediatric neurologist and geneticist Markus Schuelke. He thought the boy might have had a muscular disease but then remembered that Se-Jin Lee, a Johns Hopkins University geneticist, had produced overly buff mice by knocking out the gene for a protein called myostatin, which is supposed to slow muscle growth. Schuelke thought here was the first evidence of a myostatin mutation in a human.

Four years later the world heard about the boy for the first time, when a group of researchers including Schuelke and Lee proved the boy had a myostatin mutation. By then the child could hold a 7-pound dumbbell in each of his outstretched hands. One writer to the New England Journal of Medicine speculated that the mythical Hercules was a myostatin mutant, too.

The news about this rare mutation precipitated an intensive effort to design drugs--call them myostatin blockers--that would let muscles flourish without onerous side effects. The work holds the most promise for patients with Duchenne muscular dystrophy, a debilitating and deadly disease diagnosed in 600 American children, almost all boys, every year. Corticosteroids and heart-failure drugs have allowed some patients to survive into their 40s, but they are still strapped to ventilators and require round-the-clock care.

"This is a like a bright light in a fairly dark tunnel," says Patricia Furlong, founder of Parent Project Muscular Dystrophy. She lost two teenage sons to Duchenne. The research also offers hope for patients with Lou Gehrig's disease and age-related weakening.

Myostatin was discovered in mice in 1992 in Lee's Johns Hopkins lab. In 1996 he proved its importance by showing that mice without the myostatin-producing gene got twice as big. The next year he discovered that the bulging Belgian Blue cow was a myostatin mutant, the first of eight prized cattle breeds later found to have the mutation. The company he had cofounded, MetaMorphix, is working on manipulating myostatin to beef up livestock. Wyeth (nyse: WYE - news - people ) picked up the rights to develop a drug for humans. Its experimental antibody drug produced bulked-up mice in 2002, and results of a trial in adults with muscular dystrophy are expected as early as March.

Already there are concerns that the drugs might be used by athletes as a kind of supersteroid, and dietary-supplement companies have introduced knockoffs made from sea algae for that purpose. "They don't work," says Schuelke.

Schuelke and Lee still see room for failure. Side effects could crop up, and Lee's work shows that real muscle growth may require a broader attack than the Wyeth drug's targeted approach, because there are a host of mysterious myostatin-like proteins that also dampen muscle growth. Lee doesn't know how many. Acceleron Pharma is set to begin human trials on a drug that mimics a cell receptor that could disable many of the myostatin-like proteins. The Cambridge, Mass. firm has raised $56 million from venture funds, including Polaris Venture Partners and OrbiMed Advisors.

Schuelke continues to see the muscular boy he found in Berlin seven years ago. Though there were fears that his heart might get too thick, the boy is completely healthy. He's strong but no longer abnormally so. It may be that myostatin's effects are most dramatic during fetal development, but that's one of many guesses in this genetic mystery.

The True Adonis

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Here is something that might help an Experimenting bodybuilder or Dog Genotyper, cattle breeder

http://www.metamorphixinc.com/

ieffinhatecardio

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they are faster out of the blocks but lack the stamina for the normal distance 200m sprints I believe.  Also may lack the aggressive character, they tend to be very docile.

They? There's more than one of these super muscular Whippets?

Can this dog Wendy function normally or is she so musclebound that she can't run or play like a normal Whippet? I almost feel bad for her.

The True Adonis

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They? There's more than one of these super muscular Whippets?

Can this dog Wendy function normally or is she so musclebound that she can't run or play like a normal Whippet? I almost feel bad for her.
Of course there is more.  Its not a freak occurrence since we know how to breed a "Bully Whippet".  She is normal but is hindered by her size of course.  Her heart may not be able to take the mass.  Keep in mind she is a little over twice the size of a normal Whippet, but the heart is the same size.


climber

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this would make a cool pet:
Hrmmm

The True Adonis

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this would make a cool pet:

A Liger eh?

climber

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A Liger eh?

Yep that's what it is... It's pretty much my favorite animal. It's like a lion and a tiger mixed... bred for its skills in magic. Close to a thousands pounds.

http://www.metacafe.com/watch/250400/liger/
Hrmmm

jr

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Will do a lot of damage on the pro circuit once the whippet brings up its foreaerms and calves.

EL Mariachi

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every human can run does that mean they shouldn't have marathons? You're thick as a brick and about 1/2 as interesting

you cant compare it like that, running is workig ,like lifting. whats myostatin? nothing! you dont have to do jack shit after myosttin.

natural al

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I don't get it.....this is supposed to be kinda a BB board, they have a petboard don't they?  why do we have to see pics of a ripped dog every week?
nasser=piece of shit

LatsMcGee

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I don't get it.....this is supposed to be kinda a BB board, they have a petboard don't they?  why do we have to see pics of a ripped dog every week?

Because the bitch has wheels dog.

Nordic Beast

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I don't get it.....this is supposed to be kinda a BB board, they have a petboard don't they?  why do we have to see pics of a ripped dog every week?
Are you retarded------------how do you not see how this relates to BBing???

This is talking about extreme muscular development through pure genetics--not training, not drugs, just mutated DNA that causes extreme development. 

I find this thread fascinating, this is far more interesting than argueing about dorian vs. coleman.

Good Job Adonis-----keep this stuff coming

Mat

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Sh1T!!!!!! That dog does look like the mutant one in the incredible hulk movie. Absolutely incredible muscle mass.

How many cases has this happened in humans? Just the two kids? It would be so interesting to see what someone with those genes could do as a natural bodybuilder.

natural al

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Are you retarded------------how do you not see how this relates to BBing???

This is talking about extreme muscular development through pure genetics--not training, not drugs, just mutated DNA that causes extreme development. 

I find this thread fascinating, this is far more interesting than argueing about dorian vs. coleman.

Good Job Adonis-----keep this stuff coming

until they do this in humans I don't see the point, wow a muscle bound dog...great, wonderful.  I saw a pic of a cow or a bull with this condition 5 years ago and I didn't get to fired up and seeing a dog with it was interesting at first but now there's a new thread on it every week.  I just don't get it.
nasser=piece of shit

HUGEPECS

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That Dog would beat Coleman and Cutler on the most muscular Pose anytime ;D .damn, Imagine a german sherpherd with a genetic mutation like this one.
Get Big, or Die Trying

shiftedShapes

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shiftedShapes

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until they do this in humans I don't see the point, wow a muscle bound dog...great, wonderful.  I saw a pic of a cow or a bull with this condition 5 years ago and I didn't get to fired up and seeing a dog with it was interesting at first but now there's a new thread on it every week.  I just don't get it.

Al are you paying any attention, they are working on a drug to block myostatin in Humans, they have done human trials, and some even say it is available on the black market.  I know one of your major goals here is to antagonize TA (and me because you think I agree with him too much) but I thought that your primary reason for being here was because you are interested in muscle development.  Can't you see that this thread is more relevant to muscle development then just about anything else that gets posted here? 

Nordic Beast

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until they do this in humans I don't see the point, wow a muscle bound dog...great, wonderful.  I saw a pic of a cow or a bull with this condition 5 years ago and I didn't get to fired up and seeing a dog with it was interesting at first but now there's a new thread on it every week.  I just don't get it.
DID U READ THE ARTICLE-----IT HAS ALREADY HAPPENED IN HUMANS!!!!!

Its only a matter of time before they figure out exactly why and how to replicate the mutation in humans.  Although signifigant progress wont be made on that until President Bush is out of office.


Nordic Beast

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Al are you paying any attention, they are working on a drug to block myostatin in Humans, they have done human trials, and some even say it is available on the black market.  I know one of your major goals here is to antagonize TA (and me because you think I agree with him too much) but I thought that your primary reason for being here was because you are interested in muscle development.  Can't you see that this thread is more relevant to muscle development then just about anything else that gets posted here? 
exaclty---your TA obession is blinding you to true signifigance of this information.

natural al

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Al are you paying any attention, they are working on a drug to block myostatin in Humans, they have done human trials, and some even say it is available on the black market.  I know one of your major goals here is to antagonize TA (and me because you think I agree with him too much) but I thought that your primary reason for being here was because you are interested in muscle development.  Can't you see that this thread is more relevant to muscle development then just about anything else that gets posted here? 

I don't worry a whole lot about TA, if it's relevent to you guys go for it I guess.  whould this really be something a "natural" guy would be allowed to use if it happens and is availible?  Is it any different than roids?  these are honest questions...not that it matters much I guess.

if I was just here to go after you and TA I'd actually put some effort into it, simply asking "what's the point of posting pics of your dog" isn't really going after anyone, is it?  I'm def. not here to go after you again if I was I'd put effort into it instead of an occasional post here and there, have I been vicious with you?  no, I don't think so. 

I've seen at least 4 threads about this in the last few weeks is all I was saying.
nasser=piece of shit

shiftedShapes

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http://www.detnews.com/apps/pbcs.dll/article?AID=/20070607/METRO/706070357/1003

This is current and is a different person than the German baby.

Yeah I read about him...he is only heterozygous for the mutation and he still was almost able to do an iron cross at 19 months.

It would be too bad if the gene had diminished effect in adults.