Sure. It wasn't just Jews who have been killed or booted out of places since year 250. Not sure why you chose that date but I'm sure you'll let us know before long. At any rate, the number of Jews killed or booted is certainly less than non Jews. Granted, this is a little bit of statistical witchery but the point is that Jews weren't the only ones who were disliked.
Can't give you dates but for a long time the church(es) in Europe declared it to be a sin for someone to make money in certain ways. Among these was money lending and I think there were others. It was probably intended to cement the superior economic power of the nobility. The Jews didn't have any such restriction placed on them by their church doctrine so they were free to engage in banking. You can't really blame the Jews because Catholic Europe imposed stupid restrictions on itself designed to stunt economic development. Nevertheless, if your neighbor is getting rich doing what you've been told is a sin, and he's living the high life while you work hard and never make any progress, you're going to grow to resent the guy. There are just as many money hungry non Jews as money hungry Jews. The Jews weren't prevented from handling money and they were disliked for the profit it afforded them.
Also, they're a minority but just as serious in their belief (if they're devout) as other faiths that they are right about God and you, if you're not a Jew, are therefore wrong. Christians are the same. Muslims are the same. It's a very annoying trait of religious people in general to insist that their faith is the only correct one, or at least a hell of a lot more correct than yours. Well, when you're a minority and you annoy the majority you tend to get killed or booted out.
HTH.
Please list all 109 locations. And are you sure you didn't mean 250 BC?