1. Take cheque drops
2. Insert mouthpiece
Love the Cheque Drops.
CHEQUE® DROPS
CII
Pharmacia & Upjohn
Estrous Preventive
Mibolerone drops
NADA No.: 102-709
Active Ingredient(s): Each mL contains 100 mcg mibolerone and propylene glycol, qs.
Indications: CHEQUE® (mibolerone) Drops are administered orally for estrous (heat) prevention in adult female dogs not intended primarily for breeding purposes. CHEQUE® Drops dosage should be discontinued after 24 months of use.
CHEQUE® Drops are effective in preventing estrus only when drug administration is initiated 30 days prior to the start of the proestrus. It should not be used in an attempt to abbreviate an estrous period. It should not be used in bitches prior to the first estrous period.
Pharmacology: CHEQUE® (mibolerone) Drops are 17-b-hydroxy-7a, 17-dimethyl-estr-4-en-3-one, generic name mibolerone, a non-progestational steroid. In its pure form, mibolerone is a white crystalline solid. The compound is stable under ordinary conditions and temperatures.
Actions: More than 90 percent of normal, mature cycling bitches did not exhibit estrus when administered CHEQUE® (mibolerone) Drops in adequate doses.
Mibolerone has been shown to be an anabolic and androgenic steroid in rats. When compared to methyltestosterone, it is 41 times more potent as an anabolic agent and 16 times more potent as an androgen. Mibolerone has no estrogenic activity in mice when used at levels up to 1.0 mg per animal per day. It is antiestrogenic in mice in intravaginal tests at 0.9 mcg and in subcutaneous tests at 10 mcg or less when tested against estradiol.
In the bitch, mibolerone has androgenic, anabolic and antigonadotrophic activity. Mibolerone selectively blocks the luteinizing hormone (LH) peak thereby preventing estrual activity. No significant progestational nor estrogenic activity has been demonstrated in the canine.
Metabolism: Based on tritium labeled studies in the bitch, approximately equal quantities of mibolerone were excreted via the urine and feces. Mibolerone was extensively metabolized, being excreted as over 10 metabolites. Mibolerone was present in most tissues with highest concentrations being in the liver, anal glands and reproductive organs. Significant levels of radioactivity occurred along the digestive tract.
Canine Efficacy: Mibolerone dosage for estrous prevention was evaluated in 13 breeds of purebred dogs in kennels. It was also field tested in a substantial number of bitches. Based on kennel trials and in home evaluations for various periods of time, more than 90 percent of normal, mature cycling bitches did not exhibit estrus when administered CHEQUE® (mibolerone) Drops in adequate dosage
