^^
You asked a good legitimate question, I'll answer it... #1 thing I was afraid of is she'd start talking to me or try to touch me.
I'm a bit of a handsome S.O.B. and look 10 years younger than I am all do to lifting.
In my experience, a simple not interested type comment works, not only with transsexuals, but pretty much anyone who comes on to you, male or female. Be nice, but also be clear. If you act flattered, you make yourself less believable and you risk not being taken seriously.