Weights are easier to control the closer they are to where you're handling the weight (e.g. try to curl a 45-lb barbell vs. a 45-lb dumbbell; DB is much easier). So I guess from that perspective, if you want to do something like bench 205 lbs, this should be marginally easier with 45+35 vs. with 45+25+10.
That's all I've got.