Turmeric?

[IroNat]

[Van_Bilderass]

Video makes me wonder what "Nutrilab" is selling

Video didn't really say much actually, what's the takeaway message?

[IroNat]

Video makes me wonder what "Nutrilab" is selling

Video didn't really say much actually, what's the takeaway message?

Turmeric's active ingredient Curcumin is believed to have anti-inflammatory properties.

1) Turmeric (active ingredient Curcumin) is very poorly absorbed by the digestive system.
2) It's BS that combining pepper with turmeric increases utilization.

[MajorDomo]

Natural substances that contain multiple hydroxy  (-OH) groups,  bound as phenols,  are strongly protective of the human body. You will find this over and over in nature.

I worked for a pharma startup that was making skin care products using natural polyphenolic compounds. The raw materials are cheap as hell but the finished products are sold for insanely high markups.

You can see the phenol structure in curcumin.

[IroNat]

Natural substances that contain multiple hydroxy  (-OH) groups,  bound as phenols,  are strongly protective of the human body. You will find this over and over in nature.

I worked for a pharma startup that was making skin care products using natural polyphenolic compounds. The raw materials are cheap as hell but the finished products are sold for insanely high markups.

You can see the phenol structure in curcumin.

Cool.

I use Turmeric a lot and always combine it with black pepper because of the "myth".

[Van_Bilderass]

Turmeric's active ingredient Curcumin is believed to have anti-inflammatory properties.

1) Turmeric (active ingredient Curcumin) is very poorly absorbed by the digestive system.
2) It's BS that combining pepper with turmeric increases utilization.

I know. It's what the video says, and I get that, but I hear something else, like "buy this instead." You know what I mean?

Whether this claim about the pepper extract, which I'm assuming refers to brand name Bioperine, holds weight is something I could look up, but that's not so interesting to me. My gut reaction is that this video is somehow disingenuous.

Regarding curcumin and it's putative positive and protective effects I read something "scientific" years ago casting some of the claims into doubt but people are probably not interested

Edit. I had to look it up for my own benefit, read it 9 years ago, holy shit I don't understand the science or chemistry so to speak but I thought then that this paper basically said that due to the type of assays used to measure biological activity it showed activity where in fact there was none. So even if bioavailability wasn't an issue it still wouldn't work as assumed. Or something, I think.

https://pubs.acs.org/jmcmar/article/60/5/1620/697421/The-Essential-Medicinal-Chemistry-of

What do you think MajorDomo?

I will look up the pepper extract bioavailability issue quickly anyway to see of the video seems to hold water.

BTW, there was a character going by the handle 'Animal' years ago on the steroid related forums that offered injectable curcumins. He was a guy who sold "Finaplix conversion kits" which were used to convert cattle ear implant pellets into usable injectables for bodybuilders.

[NaturalWonder83]

Don't waste your money on stupid turmeric supplements! Do you really think that some powder that sits in a bottle on a hot FedEx truck and then sits on shelves for months and months is really going to heal your body? If turmeric did anything, hospitals and doctors would be prescribing it instead of drugs. People would be healed and turmeric would be sacred to the world.

Cooking with it is okay I guess. It gets allllllllll over your hands and stains your palms and fingers!  I think Indian food uses a lot of turmeric. Nothing worse than your Indian neighbors in an apartment building cooking curry and now the hallways, stairwells, your apartment, and bed comforter reeks of curry!

[Van_Bilderass]

Don't waste your money on stupid turmeric supplements! Do you really think that some powder that sits in a bottle on a hot FedEx truck and then sits on shelves for months and months is really going to heal your body? If turmeric did anything, hospitals and doctors would be prescribing it instead of drugs. People would be healed and turmeric would be sacred to the world.

That's not necessarily true, at all

Whether turmeric in the specific "works" or is useful is another discussion

I'll give a quick example. Berberine has been shown to be as effective as Metformin as a diabetes drug. Docs aren't prescribing Berberine.

[deadz]

Turmeric's active ingredient Curcumin is believed to have anti-inflammatory properties.

1) Turmeric (active ingredient Curcumin) is very poorly absorbed by the digestive system.
2) It's BS that combining pepper with turmeric increases utilization.

Bioperine would increase bioavailability.

[IroNat]

Bioperine would increase bioavailability.

I think regular black pepper also contains whatever it is.

[Van_Bilderass]

2) It's BS that combining pepper with turmeric increases utilization.

I looked it up for 3 minutes and I think what the video references is a 1998 pharmacokinetic study involving brand name Bioperine at 20mg combined with 2 grams of curcumin showing an 2000% increase in bioavailability. The active in black pepper is piperine and there "just" being that "single" study involving that specific branded product doesn't necessarily mean that piperine doesn't increase curcumin bioavailability. My wild guess is that piperine does increase bioavailability of curcumin along with many other compounds as show by animal data. Hence my immediate hunch that the video was actually selling some other solution to the bioavailability issue. You know what I mean?

Key Mechanisms

Inhibiting Metabolic Enzymes: Piperine blocks specific enzymes (such as CYP3A4 and glucuronyl transferases) in the liver and intestine. These enzymes normally destroy active ingredients like curcumin or certain drugs before the body can use them.

Blocking Efflux Pumps: It inhibits P-glycoprotein, a cellular pump that normally pushes foreign molecules and toxins back out of intestinal cells. Stopping this pump keeps the molecules inside the cells longer. 

Improving Intestinal Permeability: Piperine alters the lipid membrane of intestinal cells, making it easier for nutrients to pass through the gut wall

I think regular black pepper also contains whatever it is.

It does. I looked it up myself a while back and it was something like 100-200mg of black pepper to equal a typical dose of Bioperine or piperine in supps, which is what Bioperine is (just a branded product).

There's another popular bioavailability enhancer often used in supps called AstraGin (brand name), a combination of Astragalus and Panax notoginseng extracts.

[IroNat]

I looked it up for 3 minutes and I think what the video references is a 1998 pharmacokinetic study involving brand name Bioperine at 20mg combined with 2 grams of curcumin showing an 2000% increase in bioavailability. The active in black pepper is piperine and there "just" being that "single" study involving that specific branded product doesn't necessarily mean that piperine doesn't increase curcumin bioavailability. My wild guess is that piperine does increase bioavailability of curcumin along with many other compounds as show by animal data. Hence my immediate hunch that the video was actually selling some other solution to the bioavailability issue. You know what I mean?

It does. I looked it up myself a while back and it was something like 100-200mg of black pepper to equal a typical dose of Bioperine or piperine in supps, which is what Bioperine is (just a branded product).

There's another popular bioavailability enhancer often used in supps called AstraGin (brand name), a combination of Astragalus and Panax notoginseng extracts.

I didn't get that impression, van.

I got the opposite...not to waste your money on Turmeric supplements.

Did you watch the entire video?  It went over the study you mentioned.

[Van_Bilderass]

I didn't get that impression, van.

I got the opposite...not to waste your money on Turmeric supplements.

Did you watch the entire video?  It went over the study you mentioned.

No I didn't know there was a longer one.

I have to believe curcumin supplements work at least in reducing pain as there's just too much anecdotal data. Many studies suggesting that and even when comparing to Rx NSAIDs, I seem to remember that it was about as strong.

While I was looking for that chemistry report I saw a post by Dante Trudel aka Doggcrapp where he claimed every single trainee he's put on it had a dramatic reduction in C-Reactive Protein, which measures general inflammation in the body, also he thought it would be really protective of the heart for PED users, and there were other things. It's interesting.

Curcumin may be another hormetic agent, i.e. it's a mild poison that is a stressor and then causes a beneficial adaptive response.

[WrongAdvices]

Does eating a bunch of turmeric cause a body odor?  Isn’t it spicy?

[IroNat]

Does eating a bunch of turmeric cause a body odor?  Isn’t it spicy?

I don't think it causes body odor.

The smell of cooking it might get into your clothes but I haven't noticed it.