I remember reading this in an old issue of Muscle Media (November 2001) about Glutamine, which goes against what just about all of you recommend for Glutamine supplementation...
Moreover, according to new research published in the American Journal of Clinical Nutrition, there may be an additional advantage to supplementing with small, frequent servings of a glutamine supplement. You see, logic would dictate that if you take a ton of glutamine, you'd expect most of what you ingest to show up where it's supposed to--which, for glutamine, is the bloodstream. However, with glutamine, that just doesn't happen. Studies show that between 50 percent to 85 percent of large glutamine loads ingested orally (as opposed to via an intravenous drip) don't reach the bloodstream. Instead, such large doses typically raise a red flag, prompting the liver to accelerate its removal from the bloodstream. Smaller loads, on the order of 2 grams to 3 grams, have been shown to increase plasma glutamine levels by about 19 percent without "provoking" the liver to initiate housecleaning duties.
T. Welbourne, "Increased Plasma Bicarbonate and Growth Hormone After an Oral Glutamine Load," Amer. J. Clin. Nutr. 61 (1995): 1058-1061.
So according to this, taking large doses of glutamine, is a complete waste of money!
