You are saying on hand there are a number of side-effects and then on other that there are no consequences if you start smoking as adult?
Also, do you agree with this guy?
Yes, side effects and consequences(inferring long term use) were meant to imply different things in my sentence.
A side effect on drinking is elevated liver enzyme, a consequence of continued usage is hepatic damage and eventual full cirrohsis.
there is nothing related to demotivation syndrome, it lowers dopamine however sativas tone DA neurotransmission. It's strain specific, anyone with any knowledge on the subject would know that.
It is less addictive then coffee or on par with it and cigarettes, it's a moot argument he should read some books on medicine. Availability has no bearing on addiction we see this everywhere. Addiction is a disease related to the reward center in your brain, namely, the mesocorticolimbic pathway and the nucleus accumbens.
His last argument sounds like he is into reefer madness? grades dropping, relationships failing. Is this guy a doctor? did he ever consider that sick people have lives that are out of control and MJ is a self medication, perhaps they would be worse? why did he jump to his biased conclusion? shit I answered that myself there.
He is dealing with MJ addicts, that's what he does, I use daily and am a doctor, I wrote this blazed off the top of my head and could rip this guys ass in two that must prove MJ makes you a doctor, puts your life in the right direction and makes your grades improve. Do you not see how silly his argument is? losers will always be losers.
On top of that he is a poor scholar, he cites a 40% stat he hauled out of his ass, if he knew anything about cannabinoids, he would know that some have anti-psychotic properties, oh ya, that demotivation that he is talking about? thats from low dopamine, what do anti-psychotics do? lower dopamine. I wonder if there is evidence to corroborate my view. looka here
Recent Pat CNS Drug Discov. 2014 Mar 6. [Epub ahead of print]
Therapeutic Potential of Cannabinoids in Schizophrenia.
Kucerova J, Tabiova K, Drago F, Micale V1.
Author information
Abstract
Increasing evidence suggests a close relationship between the endocannabinoid system and schizophrenia. The endocannabinoid system comprises of two G protein-coupled receptors (the cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle Δ9-tetrahydrocannabinol), their endogenous small lipid ligands (namely anandamide [AEA] and 2-arachidonoylglycerol [2-AG], also known as endocannabinoids), and proteins for endocannabinoid biosynthesis and degradation. It has been suggested to be a pro-homeostatic and pleiotropic signalling system activated in a time- and tissue-specific manner during pathophysiological conditions. In the brain, activation of this system impacts the release of numerous neurotransmitters in various systems and cytokines from glial cells. Hence, the endocannabinoid system is strongly involved in neuropsychiatric disorders, such as schizophrenia. Therefore, adolescence use of Cannabis may alter the endocannabinoid signalling and pose a potential environmental risk to develop psychosis. Consistently, preclinical and clinical studies have found dysregulations in the endocannabinoid system to alter blood and/or cerebrospinal fluid biochemistry. It has been proved that changed expressions of CB1 and CB2 receptors were linked to altered levels of AEA and 2-AG in the cerebrospinal fluid and/or blood. Thus, partial efficacy of antipsychotic compounds which manipulate this system may provide a novel therapeutic target for the treatment of schizophrenia. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of schizophrenic symptomatology.
Furthermore, this review will be highlighting the therapeutic potential of cannabinoid-related compounds and presenting some promising patents targeting potential treatment options for schizophrenia."His view is that of a simpleton. He is a doctor true and true, doesn't keep up to date on the research.
On top of that we have viable strategies to reduce addiction, NAC has been studied as it lowers glutamate intracellularly by shifting extracellular vesicle production, in turn it reduces addictive tendencies.
Eur Neuropsychopharmacol. 2014 Jan;24(1):51-64. doi: 10.1016/j.euroneuro.2013.11.002. Epub 2013 Nov 15.
Cannabidiol as a potential treatment for psychosis.
Schubart CD1, Sommer IE2, Fusar-Poli P3, de Witte L2, Kahn RS1, Boks MP4.
Author information
Abstract
Although cannabis use is associated with an increased risk of developing psychosis, the cannabis constituent cannabidiol (CBD) may have antipsychotic properties. This review concisely describes the role of the endocannabinoid system in the development of psychosis and provides an overview of currently available animal, human experimental, imaging, epidemiological and clinical studies that investigated the antipsychotic properties of CBD. In this targeted literature review we performed a search for English articles using Medline and EMBASE. Studies were selected if they described experiments with psychosis models, psychotic symptoms or psychotic disorders as outcome measure and involved the use of CBD as intervention. Evidence from several research domains suggests that CBD shows potential for antipsychotic treatment.
So this guy has been caught is several half truths so far, before I go on, let me geuss he is a christian right winger? I don't agree with anything he is saying to be honest. It has clear medicinal benefits and adults should be able to do as they please, why would anyone favor prohibition, is colorado not enough evidence?
Like I said, you need a susceptibility to psychosis for MJ to induce it, it's because the endocannabinoid system plays a role in schizophernia. These individuals appears to have alterations in the CB1/CB2 receptor which predispose them to psychosis, the mj pushes them over the edge so to speak. Also, psychosis and schizophrenia are not the same, you can have acute psychosis (trip out) and be fine, the number is inflated because psychosis is a dynamic state. Many drugs induce it, however, mj induces psychosis which appears to break into schizo for those with the genes for it.
The truth is that this drug is less harmful then alcohol or tobacco and by a wide margin.