i do TRT these days,right now im taking off 3 months from the TRT. HONESTLY i believe if a person gets yearly CHECK UPS/BLOOD WORK, even every 6 months if they choose and EATS CLEAN they can live a good long life like they where supposed to. i dont smoke,eat clean,i have a cheat meal once a week but no ones perfect i guess,it helps me though so i cant complain.my only down fall was rec drug usage,i started using opiates last year but im getting treated for it now and ill b off the medication soon,i dont drink either,i have in the past but never ever a alcoholic.weekend warrior drinker,friday night type of thing when i used to do it in my younger years. what im saying is if a person uses TRT, EATS CLEAN,STAYS AWAY FROM STUFF LIKE CIGARETTES,ALCOHOL,LIMITS STRESS AS MUCH AS POSSIBLE AND IS HAPPY THERES NO REASON WHY HIS LIFE HAS TO BE SHORTENED BY TRT USING,IM TALKING ABOUT TRT HERE NOW (NOT REGULAR HEAVY STEROID ABUSE)thats a whole nother story and YES i think that will have some negative affects in the LONG RUN being on LARGE DOSAGES for LONG PERIODS OF TIME