It's my understanding that there's more involved than the AR's ability to bond, since ARs are saturated at low doses yet anabolic benefits continue to increase with higher doses.
Can you define exactly what you mean by "upregulation" since I may not be understanding you as you intend? Also, how do you propose to accomplish this?
Supposedly there are a bundle of new drug therapies based on the up-regulation of cell receptors (most of this research was aimed at improving insulin utilization, but now they've got the newly discovered GDF [growth and differentiation factor] intracellular hormones to play with so the research has stumbled into the area of muscle growth: myostatin and other GDF proteins).
Seemingly the effect of a hormone can be potentiated/"upregulated" by:
-increasing receptor numbers (obvious)
-increasing receptor sensitivity
-increasing receptor affinity (length of binding)
-short-circuiting the receptor down-regulation feedback mechanisms
-increasing the capacity of the INTRAcellular mechanisms activated by the hormone
I was just interested if any of the steroid users are trying anything along these lines?
The more I read about steroid use the more I'm amazed by the haphazard approach taken by so many. It's just a take what the pros take and hope your health holds out long enough for you to catch up size wise approach.
Why does no one spend any time or effort considering alternative approaches... heavy lactoferrin supplementation, heavy fatty acid supplementation (omega 3, 6 & 9, EPA, DHA, GLA etc), l-leucine drips are all well proven methods for increasing muscle mass and both CLA (the bio-active isomers) and HMB have proven clinical benefits yet no one seems to be willing to try megadosing these over the counter supplements.
I just wonder how much of this super-dose AAS approach is hampered by a lack of substrates in the muscle cell?
The Luke
PS-thanks for you answer Tapeworm.
