Getbig Bodybuilding, Figure and Fitness Forums
April 23, 2014, 09:01:16 PM *
Welcome, Guest. Please login or register.

Login with username, password and session length
 
   Home   Help Calendar Login Register  
Pages: [1]   Go Down
  Print  
Author Topic: Long R IGF-1 preserves muscle in catabolic cows  (Read 846 times)
!@#$%
Getbig III
***
Posts: 313



View Profile
« on: November 29, 2006, 07:36:35 PM »

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T62-47YYBM5-3&_coverDate=05%2F31%2F1999&_alid=498479924&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5018&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7d4728646b0f1959a8e4838ad72ec4f6

Abstract

Insulin-like growth factor-1 (IGF-1) is perhaps the most important endogenous factor controlling growth. Most studies to date in livestock have shown that IGF-1 has greatest efficacy when animals are in a catabolic state. We have determined the effects of an iv infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding. There was a tendency for both whole-body protein and skeletal muscle protein to be conserved in Long(R3)-IGF-1-treated heifers. Long(R3)-IGF-1 administration markedly reduced the plasma concentrations of all amino acids measured and glucose. There was a significant change in the profile differences of endogenous plasma IGF-1 concentrations during the 8-hr infusion period, with plasma IGF-1 decreasing sharply in the test group. There was a significant difference in mean profiles for plasma IGF-2 between the test and control groups. Overall, plasma IGF-2 for the control group decreased only slightly over time (about 40 ng/ml), whereas the test group decreased dramatically (by about 140 ng/ml). Increased plasma concentrations of a 3132-kDa IGF-binding protein (possibly IGF-binding protein-1) in the treated group was detected by radioligand blot. We found that Long(R3)-IGF-1 infusion tended to preserve whole-body and muscle protein in beef heifers on a low-quality diet, and suggest that further investigation of this treatment may provide an alternative approach to reducing weight loss during the dry season.
Report to moderator   Logged
DIVISION
Getbig V
*****
Gender: Male
Posts: 16280


Bless me please, father.....


View Profile WWW
« Reply #1 on: November 29, 2006, 08:53:54 PM »

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T62-47YYBM5-3&_coverDate=05%2F31%2F1999&_alid=498479924&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5018&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7d4728646b0f1959a8e4838ad72ec4f6

Abstract

Insulin-like growth factor-1 (IGF-1) is perhaps the most important endogenous factor controlling growth. Most studies to date in livestock have shown that IGF-1 has greatest efficacy when animals are in a catabolic state. We have determined the effects of an iv infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding. There was a tendency for both whole-body protein and skeletal muscle protein to be conserved in Long(R3)-IGF-1-treated heifers. Long(R3)-IGF-1 administration markedly reduced the plasma concentrations of all amino acids measured and glucose. There was a significant change in the profile differences of endogenous plasma IGF-1 concentrations during the 8-hr infusion period, with plasma IGF-1 decreasing sharply in the test group. There was a significant difference in mean profiles for plasma IGF-2 between the test and control groups. Overall, plasma IGF-2 for the control group decreased only slightly over time (about 40 ng/ml), whereas the test group decreased dramatically (by about 140 ng/ml). Increased plasma concentrations of a 3132-kDa IGF-binding protein (possibly IGF-binding protein-1) in the treated group was detected by radioligand blot. We found that Long(R3)-IGF-1 infusion tended to preserve whole-body and muscle protein in beef heifers on a low-quality diet, and suggest that further investigation of this treatment may provide an alternative approach to reducing weight loss during the dry season.

I guess it pays to be a catabolic cow.....

Too bad the results can't be correlated to humans.



DIV
Report to moderator   Logged

I'm a ghost in these killing fields...
!@#$%
Getbig III
***
Posts: 313



View Profile
« Reply #2 on: November 30, 2006, 04:33:58 PM »

I guess it pays to be a catabolic cow.....

Too bad the results can't be correlated to humans.



DIV

The physiology of humans is not that different from cows. Trenbolone is a bovine steroid.
Report to moderator   Logged
DIVISION
Getbig V
*****
Gender: Male
Posts: 16280


Bless me please, father.....


View Profile WWW
« Reply #3 on: December 01, 2006, 10:47:46 PM »

The physiology of humans is not that different from cows. Trenbolone is a bovine steroid.

Yes, it is.

......but I'm not risking my health over some study on cows.

I didn't use Tren until there was reliable feedback years later from people who had been on it for awhile.

I don't advocate being a human guinea pig.



DIV
Report to moderator   Logged

I'm a ghost in these killing fields...
Pages: [1]   Go Up
  Print  
 
Jump to:  

Theme created by Egad Community. Powered by MySQL Powered by PHP Powered by SMF 1.1.16 | SMF © 2011, Simple Machines Valid XHTML 1.0! Valid CSS!