Long R IGF-1 preserves muscle in catabolic cows

[!@#$%]

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T62-47YYBM5-3&_coverDate=05%2F31%2F1999&_alid=498479924&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5018&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7d4728646b0f1959a8e4838ad72ec4f6

Abstract

Insulin-like growth factor-1 (IGF-1) is perhaps the most important endogenous factor controlling growth. Most studies to date in livestock have shown that IGF-1 has greatest efficacy when animals are in a catabolic state. We have determined the effects of an iv infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding. There was a tendency for both whole-body protein and skeletal muscle protein to be conserved in Long(R3)-IGF-1-treated heifers. Long(R3)-IGF-1 administration markedly reduced the plasma concentrations of all amino acids measured and glucose. There was a significant change in the profile differences of endogenous plasma IGF-1 concentrations during the 8-hr infusion period, with plasma IGF-1 decreasing sharply in the test group. There was a significant difference in mean profiles for plasma IGF-2 between the test and control groups. Overall, plasma IGF-2 for the control group decreased only slightly over time (about 40 ng/ml), whereas the test group decreased dramatically (by about 140 ng/ml). Increased plasma concentrations of a 31–32-kDa IGF-binding protein (possibly IGF-binding protein-1) in the treated group was detected by radioligand blot. We found that Long(R3)-IGF-1 infusion tended to preserve whole-body and muscle protein in beef heifers on a low-quality diet, and suggest that further investigation of this treatment may provide an alternative approach to reducing weight loss during the dry season.

[DIVISION]

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T62-47YYBM5-3&_coverDate=05%2F31%2F1999&_alid=498479924&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5018&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7d4728646b0f1959a8e4838ad72ec4f6

Abstract

Insulin-like growth factor-1 (IGF-1) is perhaps the most important endogenous factor controlling growth. Most studies to date in livestock have shown that IGF-1 has greatest efficacy when animals are in a catabolic state. We have determined the effects of an iv infusion of the IGF-1 analog Long(R3)-IGF-1 on protein metabolism in beef heifers that were slowly losing liveweight because of restricted feeding. There was a tendency for both whole-body protein and skeletal muscle protein to be conserved in Long(R3)-IGF-1-treated heifers. Long(R3)-IGF-1 administration markedly reduced the plasma concentrations of all amino acids measured and glucose. There was a significant change in the profile differences of endogenous plasma IGF-1 concentrations during the 8-hr infusion period, with plasma IGF-1 decreasing sharply in the test group. There was a significant difference in mean profiles for plasma IGF-2 between the test and control groups. Overall, plasma IGF-2 for the control group decreased only slightly over time (about 40 ng/ml), whereas the test group decreased dramatically (by about 140 ng/ml). Increased plasma concentrations of a 31–32-kDa IGF-binding protein (possibly IGF-binding protein-1) in the treated group was detected by radioligand blot. We found that Long(R3)-IGF-1 infusion tended to preserve whole-body and muscle protein in beef heifers on a low-quality diet, and suggest that further investigation of this treatment may provide an alternative approach to reducing weight loss during the dry season.

I guess it pays to be a catabolic cow.....

Too bad the results can't be correlated to humans.



DIV

[!@#$%]

I guess it pays to be a catabolic cow.....

Too bad the results can't be correlated to humans.



DIV

The physiology of humans is not that different from cows. Trenbolone is a bovine steroid.

[DIVISION]

The physiology of humans is not that different from cows. Trenbolone is a bovine steroid.

Yes, it is.

......but I'm not risking my health over some study on cows.

I didn't use Tren until there was reliable feedback years later from people who had been on it for awhile.

I don't advocate being a human guinea pig.



DIV