Yes. a linebacker I played with who's now in the NFL. He had a lumbar disk injury and the radiopathy (pinched nerve) prevented him from putting any mass in his calves/hams. Use it or loose it. Stop eyeing guy's legs...
In the pro ranks, Dennis Wolf fits that description. His physique is spectacular until you get to his calves, which are terrible.
This guys calves are massive compared to the guy in the gym. He literally had calves like a 120 pound 12 year old.