Let's set the scenario(s):
At 15-0, the Patriots have locked up home-field advantage throughout the AFC playoffs.
They have a chance at history - no team has ever completed the regular season 16-0. With the first-round bye, there's no need to 'rest' anyone at this point...too many weeks off would be bad for the players anyway.
So, let's say that the Patriots have a 10-point lead going into the 4th quarter next weekend against the Giants.
You're the coach - do you:
A) Pull your starters and hope your reserves can preserve the victory?
B) Leave in your starters until only 4 or so minutes remain and you're certain you've got the game in hand?