Has Anybody Heard Of Ape Growth Hormone.

[KillerMonk]

I was reading a Book about Growth Hormone exstracted from Chimpanzes in the late 70s early 80s.The Book is Australian and recounts the Bodybuilding career of a Bodybuilder, its called "Over the Edge"Very good read set in the late 80s early 90s.
In it states that some BBs fell ill to the growth hormone.Anybody in the know anything about this.
About 3 years ago a couple of Cyclists were caught using Equine(Horse)growth hormone and were banned from the IOC for a number of years.
What makes people do this shit,any input would be helpful.

[Van_Bilderass]

I know Equine growth was used by a lot of bb'ers a few years ago, called Equigen from Australia. The sellers of the stuff said it was really human growth but on the other hand this product had to be used at like 15-30iu to be "effective".

http://www.anabolicextreme.com/anabolic/new_archives/anex_archive_issue54_QA.htm

[KillerMonk]

I know Equine growth was used by a lot of bb'ers a few years ago, called Equigen from Australia. The sellers of the stuff said it was really human growth but on the other hand this product had to be used at like 15-30iu to be "effective".

http://www.anabolicextreme.com/anabolic/new_archives/anex_archive_issue54_QA.htm

Thankyou.

[no one]

equine growth is not effective in the human body as the peptide chain contains 192 amino acids, unlike human gh which contains 191.

those who use it report lesions and welts at the site of injection.

it seems it is rejected by the human body when administered and the substance therefore has no real role in contributing to the betterment of performance related tasks.

[MAXX]

Arnold used it alot thats why his jaw/mouth looked much like an apes.

[HTexan]

Arnold used it alot thats why his jaw/mouth looked much like an apes.

a plastic surgeon fix that!!!    

[KillerMonk]

What I think is more disturbing is that in the 90s when HGH was first being used it was harvested from dead bodies 

Actually HGH was synthetic around 1990 it was in the 70s 80s that HGH was taken from cadavers.

[knny187]

I was told Platz tried this stuff


but thats neither here nor there

[timfogarty]

rHGH was first produced from E. coli  in 1982, but it did not reach the market in significant quantities until the late 1980s.   Prior to that, HGH was extracted from the pituitary gland of adolescent male cadavers who had died of trauma.    Since it is a lot easier to grow E. coli than to find adolescent male cadavers who died of trauma, it is unlikely that any HGH on the black market has come from cadavers since 1990.

[onlyme]

If I remember it was from Rhesus Monkeys.  This was back in the late 70's early 80's.

[timfogarty]

If I remember it was from Rhesus Monkeys.  This was back in the late 70's early 80's.

human growth hormone only comes from humans (and genetically modified bacteria) and is the only type that will work in humans

[Max_Rep]

If I remember it was from Rhesus Monkeys.  This was back in the late 70's early 80's.

Everyone talked about Rhesus Monkey growth hormone from Grymko to Steve Michalik. The rumor was that Robby and Platz were using it but who knows if even that was true. 

[Epic_Monster]

Everyone talked about Rhesus Monkey growth hormone from Grymko to Steve Michalik. The rumor was that Robby and Platz were using it but who knows if even that was true. 

What the hell?

[knny187]

Everyone talked about Rhesus Monkey growth hormone from Grymko to Steve Michalik. The rumor was that Robby and Platz were using it but who knows if even that was true. 

Well, whatever made platz's jaws jump out....made the suspicion even more real

[Gym dude]

I have not heard of ape growth hormone up until now.

[whateva]

Ape growth hormone doesn't work

[oldman]

when I was in the military, we used it on subjects.  the result...some call him yeti or bigfoot.  we screwed up.  it affected the brain...its one of the biggest mistakes we made.  now its out...

[aliamini]

Growth was used from the 60s till the early 80s by taking from animals pituitary gland and injecting them … it was also called Somatotropin or Cadaver-GH … synthetic was produced in 84 by Elli Lilly … who actually stopped producing it last year I guess cause they didn’t see it feasible and it is not used in a lot of cases … Growth hormone was used by bbers in mid 80 … meaning … athletes were asking about it before it was released … and scientists were shocked how the hell they know about it and that athletes inquires were more that other scientists and doctors

The Horse growth is attached with a substance (can’t remember the name) that the body can’t recognize it and will release anti bodies to break it down … Horse growth is not Somatrem (192 amino acid sequence growth hormone) ... however the antibody case applies to Somatrem as well

I hope you gguys know that Equigen is a brand name for one of the boldenone undecylenate which is manufactured by Tornel containing 50 mg/ml

I remember oonce a guy got me a bottle of Equigen (boldenone undecylenate) and told me he bought as and thought it is growth hormone … so I told him he was scammed

I read the below case some couple of years back but bever identified what EquiGEn it was or they meant … anyway these WADA guys are not always updated … and might have though that Eguigen (boldenone undecylenate) is actually a HGH or assumed so cause they found it in the fridge.

http://www.smh.com.au/articles/2004/06/20/1087669847961.html?from=moreStories

[Van_Bilderass]

rHGH was first produced from E. coli  in 1982, but it did not reach the market in significant quantities until the late 1980s.   Prior to that, HGH was extracted from the pituitary gland of adolescent male cadavers who had died of trauma.    Since it is a lot easier to grow E. coli than to find adolescent male cadavers who died of trauma, it is unlikely that any HGH on the black market has come from cadavers since 1990.

I know guys who used this cadaveric growth just a couple of years ago. I know of one pro who used it as well.

[Moosejay]

Some where pushing 'rhesus monky hormone' in the 80's...it was BS

[timfogarty]

I know guys who used this cadaveric growth just a couple of years ago. I know of one pro who used it as well.

what evidence do you have that it is from cadavers? 

the cost of manufacturing it from cadavers would be so much more than what the synthetic version costs, and the risk of Creutzfeldt-Jakob Disease (mad cow) is very real.

[Van_Bilderass]

what evidence do you have that it is from cadavers? 

the cost of manufacturing it from cadavers would be so much more than what the synthetic version costs, and the risk of Creutzfeldt-Jakob Disease (mad cow) is very real.

William Llewellyn had it analyzed IIRC. There's an article on it on bodyofscience.com.

Edit, here:
http://www.bodyofscience.com/files/counterfeit_summer2005.pdf

[JohnnyVegas]

I know guys who used this cadaveric growth just a couple of years ago. I know of one pro who used it as well.

100% BULLSHIT!

The ONLY GH in the late 70's/early 80's came from the pituitary glad of recently deceased people. It was extracted and it was used primarily for promoting growth in children who had deficient pituitary glands. The cost was tens of thopusands of dollars, NO BBER could afford it at that price-despite the claims of many from the early 80's.

In 1983 pharmaceutical firm Eli Lily developed the first synthetic GH, it was branded Humatrope, and this is what all BBers at that time were being prescribed, and even though it was synthetic, it was VERY EXPENSIVE. Bob Paris spent $2K for a 4 week supply (don't know the dosage levels though) when he won Nationals in 1984.

NO ONE today gets GH from cadaver's today, NO ONE.

http://www.humatrope.com/index.jsp

Hope this helps.

[Van_Bilderass]

100% BULLSHIT!

The ONLY GH in the late 70's/early 80's came from the pituitary glad of recently deceased people. It was extracted and it was used primarily for promoting growth in children who had deficient pituitary glands. The cost was tens of thopusands of dollars, NO BBER could afford it at that price-despite the claims of many from the early 80's.

In 1983 pharmaceutical firm Eli Lily developed the first synthetic GH, it was branded Humatrope, and this is what all BBers at that time were being prescribed, and even though it was synthetic, it was VERY EXPENSIVE. Bob Paris spent $2K for a 4 week supply (don't know the dosage levels though) when he won Nationals in 1984.

NO ONE today gets GH from cadaver's today, NO ONE.

http://www.humatrope.com/index.jsp

Hope this helps.

This is not American or western growth as you can see. It's also possible it was stolen before diverted to the black market. Lots of possibilities. Also, why would someone make a counterfeit cadaver growth when he knows most will not touch it. The guys I know who used it said it did work.

Did you read the article I linked?

A sample was sent in for analysis,which
contained on the vial the text “COMATOTPOHNH”,
Fa.Endokrininai”.After the isoelectrical
focussing, several intense peaks in
the pH-area of 4.6 to 5.2 showed up in the
examined sample, next to main peaks in
pH-5.2. In the older comparison substance
(BRP) made from cadaveric pituitaries, similar
secondary peaks were also observed.The
secondary peaks are to be led back probably
to the hydrolysis of asparagine-and glutamine-
side chain of the protein to the corresponding
desamido-forms. Through the
transformation of the acidamidgroups in
carbonacidgroups, the isoelectrical point of
the protein shifts itself into the sour area.Preferred
attack points for the hydrolytical dismantling
are the exposed acidamidgroups of
asparagine in position 149 and 152 of the
polypeptide-chain [32, 33].
The demand of the medicine book
monograph according to secondary peaks
with an intensity of no more than 6.25% of
the intensity of the head volumes may
appear, was therefore not fulfilled in the
analysed preparation. In the test on related
substances by means of reversed-phase
HPLC, a peak was seen in the retention time
of somatropin, but several intensive secondary
peaks with shorter retention times
also occured.The purity request of the medicine
book-monograph was not fulfilled (sum
of the peakareas of the secondary peaks
<13%) for this sample. By means of ESIMass-
spectrometry, the active agent somatropin
could be proved unambiguously by
the mass-spectrometrical detection of the
molecule ion in the expected mass at 22,125
D in the sample. The additional observed
intensive signals in 22,224 D and in 22,322
D and the altogether quite unclean measured
spectrum referred to pollution through
accompanying proteins and decomposition
products. In the analysis through SDS-Polyacrylamide
electrophorese, the sample clearly
showed numerous additional volumes next
to the head volumes in 22 kD and a. in 20 kD
and 44 kD.The model of the protein pollution
was very similar to that of the comparison
substance (BRP),made from cadaveric
pituitary material. The presence of that 20-
kD-volumes in the sample proved that it concerned
indeed a growth hormone preparation
made out of human pituitaries, not synthetic
rHGH!

This was a 2005 article. It also says:

Cadaveric Growth Hormone
Before the introduction of genetic methods
of manufacturing recombinant proteins,
human growth hormone was obtained by
extracting it from the pituitaries of corpses.
Because of the risk of the transmission of
infectious diseases such as the rare neurological
disorder Creutzfeldt-Jakob-Desease
[1 –4],and other infectious diseases such as
hepatitis B and C, growth hormone preparations
extracted from human pituitaries
were taken off the market in the European
Union in the middle of the 1980’s [17]. After
that point, only genetically produced (synthetic)
growth hormone preparations have
been legal in the E.U. Such products are
manufactured by recombinant technology.
Growth hormone preparations manufactured
with human cadaveric pituitaries are
still available on the black market in Europe.
If an athlete uses such preparations, they
need to understand that a risk of the trans-
mission of disease exists.Because the risks of
a medication aren’t always disclosed in the
underground drug scene, a slighter lower
price might be allowed to be the decisive
factor in purchasing a risky biological GH
product. Nevertheless, we urgently warn
against using such preparations.

[JohnnyVegas]

There would be NO reason to take GH from cadavers today;

1- The COST

It is 100's of times cheaper and easier to use synthetic-so I do not believe the claim that there is GH coming from cadavers in this day and age.

2- The risks of infectious disease

It is VERY high, so again, it would be beyond stupid to use cadaver GH today. Maybe back in the late 70's, when there was no choice, but not today.

You must remember why no one used real GH, before Humatrope. There was simply a very small supply, you could NOT get large amounts of GH because it came from DEAD PEOPLE, and the amounts you could get were very small. It would take many dead people to make a cycle (I would imagine, can't say I really know-but if you know what the pituitary glad looks like, it is very small, no bigger than a nickel).

I also have to question the part of the article that says it could tell the difference between synthetic and real GH.



Now, is it possible some moron is getting cadaver GH, I guess so- but it would be stupidity at it's finest hour.

Plus the article is basically making a hearsay, third party uninformed statement. Unless they personally knew GH was coming from cadavers, with their own eyes, I do not believe it.

It just does not make any sense given the cheap cost of synthetic GH today and the safety factor.