Let's face it guys, whether you're for or against the use of roids, it's a fact that most androgens will cause negative changes to your LDL/HDL levels while you're on a cycle. Even small doses of anavar can do this. What do you think taking 1 to 3 grams of test year round like some pro's do does to your arterial plaque levels ? It can't be that good. Keep in mind that anti-aromatase and anti-estrogens also mess with cholesterol levels. I predict you will see lots of Pro's with heart problems as they hit their mid-40's. Also there are studies that suggest that long term steroid use can cause irreversable heart valve changes. My honest belief is that small doses of steroids cycled for a few months at a time a few times a year probably won't harm most healthy people. But taking 1to 3 grams of test a week, 8 to 12iu's of gh a day, Insulin and IGf1 mixed with Thyroid drugs, Anti-estrogens, clenbuterol for long drawn out cycles could prove to have negative consequences in an athlete's later years. Only time will tell, but some Pro's are starting to see the damage already. Of course someone who is on these stacks will defend it and claim, "If it was that bad, the guys would be dropping dead like flies. They're perfectly safe, jackass!"