There are a few loopholes which protect us, but also a few issues which hurt us.
When you make a lot of money, the expectation is that you'll be able to find more ways to squirrel your money away. DO WHAT IS EXPECTED OF YOU. Put in the time and figure out the best ways to decrease your taxable income. You make a lot of money, you earned it, you should be able to keep a large portion of it.
Where you get screwed, though, is in areas like your medical care. You can deduct your premiums, but if you 'only' spend $5000 out of pocket on, say, dental care, then you're toast, cuz that amount - while significant - is too small a percentage of your annual income for you to be able to deduct it. This was under the Bush tax rules and will continue under Obama.