I've added links to one pubmed abstract per ingredient... some appear to be toxic, while others show no value... some apparently have value in rodents or people...
Here's the catch... some of the ingredients are far more expensive than others and the industry is not quality controlled on inspected (hello species nutrition) so how do you know that the pills have anything more than a hint of the valuable ingredients? and conversely how do you know that they are not loaded with the toxic ones...
you see value in a supplement that you are adding to a diet and training regimen... you have no idea if it's doing any more than a sugar pill would... although i would suggest that sugar pills are far less potentially toxic...
http://www.nutraplanet.com/product/lean-body-formulations/recompadrol-180-caps.htmlRecompadrol (180 caps)
Manufactured By: Enhanced Body Formulations (LBF)
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Availability:In Stock, Ships in 1-2 Business Days Lean Body Formulations' Recompadrol: Optimal Insulin Mimicer!
Recompadrol represents the most versatile and complete nutrient re-partitioner that can be used by almost anyone. It is quickly gaining popularity for its unmatched effectiveness for any goal. Recompadrol has raised the bar and will soon become the standard by which all other Nutrient re-partitioners will be compared to.
For those who want to increase lean muscle mass, Recompadrol aids this process through super glycogen compensation and amino acid uptake, increased creatine utilization, increased insulin sensitivity and improved strength, Recompadrol should also be used by those trying to reduce body fat because of its potent effect of blocking fatty acid synthesis through ATP-Citrate Lyase, and also functioning as a PPAR-Alpha Agonist and a PPAR-Gamma Antagonist.. This makes dieting easier.
Recompadrol is not just for bodybuilders to gain an edge on the competition, or for athletes looking for better endurance. It is also for the general public looking to achieve a better health status. As shown in various studies the ingredients in Recompadrol were shown to reduce the symptoms of metabolic syndrome. Metabolic syndrome has many different meanings as proposed by various organizations ranging from the World Health Organization to the American Diabetic association. The most common parameters that Recompadrol may help with are lipid levels, glucose levels, and body fat levels. These ingredients have been shown to: activate Glut-4 in skeletal muscle tissue, lower fasting and post prandial blood glucose levels, attenuate fat gain, increase lipid oxidation, Block glucose uptake in fat cells, block triglyceride uptake in fat cells, and improve your lipid profile, just to name a few. What this means for you is that you can now successfully gain lean muscle and lose fat at the same time, all while being able to enjoy your carbohydrates. Lean Body Formulations is dedicated to bringing you the most effective, highest quality products available today. We don’t settle for average formulas due to costs, we bring you the most synergistic combinations of clinically studied compounds with the full doses used in Human trials.
A quick glance will reveal a few commonly seen ingredients, but the extracts used in Recompadrol are unlike any other product. For example Berberine HCL is not a plant extract but rather a synthetic compound. The difference between plant extract and synthetic compound is most importantly the fact that with a synthetic compound there is no variance in percentages of extract which can make one bottle of a given product work well and another less than expected. Another advantage of Berberine HCL is decreased frequency of stomach issues as seen with other products containing Berberine. So far none of the testers have had any problems with taking Recompadrol due to upset stomach. The RECOMP COMPLEX does not stop with just berberine it is much more complete. Insulin and GH are two of the most coveted hormones in the bodybuilding community. Unfortunately the use of GH lowers insulin sensitivity. With the use of Recompadrol you can not only make GH more effective in terms of fat loss but also in terms of reversing the decrease in insulin sensitivity leading to more muscle accrual. Another use for Recompadrol is to not only enhance the gains from the use of hormones, but to protect cholesterol values from reaching unhealthy levels and also preventing the binding of LDL to the walls of arteries , decreasing the risks of Cardiovascular related diseases.
Recompadrol is also and excellent adjunct or alternative to Oral hypoglycemics used by those diagnosed with Type 2 diabetes. There are many anti-hyperglycemic agents that help with insulin resistance. One of specific importance is a biguanide called Metformin. Metformin decreases hepatic glucose production and sensitizes the tissues at the cellular level to uptake glucose into muscle and adipose tissue. This is needed in individuals who are insulin resistant due to the receptor dysfunction which makes it hard to get glucose into these cells. These medications have different mechanisms and are commonly used in combination with one another to achieve a better outcome. Recently, some dietary supplements have been shown to act similarly to these oral medications to assist in offsetting the progression of insulin resistance, dyslipidemia, and obesity. Unfortunately with the use of these oral hypoglycemics most individuals will actually gain more adipose tissue only furthering their troubles. Almost all of the herbs used in the product have been used in both Ayurvedic and Chinese medicine to treat both obesity and diabetes. Berberine was compared with Metformin and Acarbose which showed “insulin sensitivity was enhanced by berberine as the HOMA-IR value was reduced by nearly 50%. This effect may be related to fat distribution by berberine because waist and waist/hip of the patients were decreased significantly in the absence of weight change. Interestingly, both fasting and postprandial C-peptides increased significantly in patients when berberine was used together with insulin, which suggests that long-term berberine treatment may improve insulin secretion of the patients with consequent failure of oral hypoglycemic agents.” Banaba which contains corosolic acid and other tannins has been shown to be just as effective in comparison to prescription oral hypoglycemics without increasing adiposity as experienced with other oral hypoglycemics such as Metformin. (*12)Ingredients Overview:Banaba
is a Asian tree that has been used in various forms for the treatment of diabetes and kidney related disease. Studies have shown that the Active extract Corosolic acid inhibits Adipocyte differentiation (preadipocyte from maturing into a fat cell), increasing glucose uptake independent of insulin through Glut-4 translocation (*1)which means your body requires less insulin to shuttle glucose into cells. Corosolic acid has also been shown to block gluconeogenis and increase glycolysis (*2) Recompadrol uses the strongest Corosolic acid extract available today, 20%, that is not found in other supplements containing Banaba. Most companies will hide there inferior product with the use of labeling such as “Highly Standardized”, “Specialized Extract” or instead not list the Percentage of Active at all. A study conducted by Fukushima, Matsuyama, Ueda, Egawa, Takemoto, Kajimoto et al., (2006) was designed to show the effectiveness of Corosolic acid in lowering post challenge plasma glucose levels in humans. In this study, 31 subjects (16 men, 15 women) were included that had fasting plasma glucose between 110 mg/dl and 140 mg/dl. Corosolic acid was administered at 10mg (lower dosage than 1 serving of Recompadrol) on different occasions in a capsule 5 minutes before the 75g oral glucose tolerance test in a double blind and cross over study. The results of the study indicated that subjects showed a lower glucose level from 60 minutes - 120 minutes, but was statistically significant at 90 minutes (p<0.05). It was theorized that the increased insulin level (with corosolic acid) 30 minutes after the test was administered may be the cause of lower blood glucose at 90 minutes. (*3)http://www.ncbi.nlm.nih.gov/pubmed/22095937Salacia Reticulata
contains the active compounds Mangiferin, Kotalanol, and salacinol. These extracts are potent PPAR alpha and PPAR gamma agonists which have been shown to , prevent postprandial hyperlipidemia, hyperglycemia, hepatic steatosis in type 2 diabetics and obese subjects.(*4,5) PPAR gamma agonists increase the burning of fat for fuel and mediate the genes responsible for fatty acid uptake, and beta/gamma oxidation which are up regulated when in a fasted state. Mangiferin also increases Glut-4 without exercise resulting in faster glycogen uptake in muscle cells. PPAR-Alpha is found in skeletal muscle, and liver tissues and is responsible for transporting fatty acids to be used for fuel and also down-regulates apolipoprotein C-III which inhibits lipid hydrolysis, which leads to enhanced lipid oxidation.http://www.ncbi.nlm.nih.gov/pubmed/12097653Vanadium
is a trace mineral that has been debated over safety. But studies have shown that Vanadium is not only effective it is also safe in amounts of 50-150mg for a period of 6 weeks with a 1-2 week break in between.(*6) The inclusion of this mineral is because of its promising use in patients with diabetes to increase insulin sensitivity and in some cases restore complete sensitivity to prediabetic levels. Used in the recommended dosages vanadium will not cause any toxic side effects that are commonly produced by those who follow “Bro-Science”(*7)http://www.ncbi.nlm.nih.gov/pubmed/23222995HCA or Hydroxycitric Acid
to block fat production by 45-70% for up to 12 hours after a meal.(*
It accomplishes this by inhibiting Citrate lyase which is responsible for creating the building blocks of fat which is Malonyl Coenzyme A. Low concentration of Malonyl Coenzyme A increases the rate of which oxidation of fat in both adipose and liver tissue.(*
HCA also increases ketone production and slows the breakdown of muscle tissue while in a hypocaloric diet. By keeping more muscle, the body will burn more fat. The greater the lean mass you have the faster the metabolic rate , which translates to less calorie restriction in periods of dieting. (*
The effect of HCA on reduced fat, namely visceral, had no rebound effect after a month of ending usage. (*9)http://www.ncbi.nlm.nih.gov/pubmed/22530711Aminoguanidine
is an important inhibitor of advanced glycation and advanced lipoxidation which are usually elevated in diabetics leading to hyperlipidemia and development of renal disease. Aminoguanidine inhibits these processes effectively. (*10) In addition, Aminoguanidine has an ability to treat patients whose blood vessels are constricted by arteriosclerosis. In 1992 at the University of Milan, 11 patients with peripheral vascular disease were treated with Aminoguanidine. Their blood vessels were so clogged that they couldn’t walk for more than 500 yards, but after treatment the patients blood flow improved on average by 30% and the patients exercise abilities improved by 50% to 105%. Another study conducted on animals showed that Aminoguanidine prevented age-related enlargement of the heart. The membrane surface area was reduced by 30%. Furthermore, the collagen content of their arterial walls was increased by 24-30%.http://www.ncbi.nlm.nih.gov/pubmed/23201071Gymnema Sylvestre
is an Indian herb which has been clinically proven to lower HbA1c, fasting blood glucose, and postprandial glucose levels dramatically (*11). Gymnema also increases the speed in which glucose is transported from the bloodstream into muscle tissue. In India a year long study was conducted using Gymnema daily, the study showed a decrease in fasting blood glucose levels from 232 mg/dL to 152 mg/dl, the control group had no change. (*12)The Gymnema group also experienced a significant drop in HbA1c(*12). In addition Gymnema has been shown to actually regenerate and multiply the number of insulin secreting beta cells in the pancreas. Regeneration and multiplication of beta cells means that those who have poor insulin sensitivity can now improve their bodies natural output of insulin. (*13)http://www.ncbi.nlm.nih.gov/pubmed/23225496Berberine
is an extract found in several different plants but has shown promise in the treatment of diabetes for numerous reasons.(*14) Berberine lowered fasting and post prandial Blood glucose levels through Glut-4 translocation and increased insulin receptor expression.(*15) . One study showed that berberine works as effectively as Metformin and it was able to improve lipid parameters more effectively. A secondary outcome of this study was a decrease in body weight. One possible reason for the weight change is that berberine increased insulin sensitivity which may be related to fat distribution; a greater reduction in LDL-c could possibly be from an up-regulation of the LDL-c receptor shown in non-human studies. (*15) Another possibility for the reduction in weight comes from inhibiting adipocyte differentiation through a specific pathway called the PPARy pathway. (*16,17)http://www.ncbi.nlm.nih.gov/pubmed/23196710
When all these ingredients are brought together in one formula you have been armed with the power to set off 3 way Glut-4 activation to extend the “muscle building window” to all hours of the day. Improved lipid profiles, lowered adipose creation, lowered prandial and post prandial Blood Glucose levels, and PPAR-Gamma Activation leads to you becoming a walking fat burning machine. Don’t settle for less than average products that hide behind fancy marketing tactics and shiny labels, try Recompadrol today and when you look in the mirror a few weeks from now you’ll be glad you did.
1. An Extract of Lagerstroemia speciosa L. Has Insulin-Like Glucose Uptake-Stimulatory and Adipocyte Differentiation- Inhibitory Activities in 3T3-L1 cells.; Journal of Nutrition, 131, 2242-2247
2. Effect of Corosolic Acid on gluconeogenesis in rat liver.; Yamada k, Hosokawa M, Fujimoto S et al.; Diabetes Research and Clinical Pract. 2008 Apr;80(1):48-55. Epub 2008 Jan 4.
3. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.; Shi, L et al.; European Journal of Pharmacology, 584(1), 21-29
4. Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin.; Girón MD et al.; Clin Nutr. 2009 Oct;28(5):565-74. Epub 2009 May 23
5. . Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in zucker diabetic fatty rats: activation of PPAR-Alpha.; Huang TH et al.; Toxicology Applied Pharmacol. 2006 Feb 1;210(3):225-35. Epub 2005 Jun 21
6. Effect of Vanadium on insulin sensitivity in patients with impaired glucose tolerance.; Jacques-Camarena O et al.; Annals of Nutrition and Metab . 2008;53(3-4):195-8. Epub 2008 Nov 22
7. Vanadium treatment of type 2 diabetes: a view to the future.; Thompson KH et al.; Journal of Inorganic Biochem. 2009 Apr;103(4):554-8. Epub 2008 Dec 24
8. Sherwin RS et al.; Journal of Clinical Invest.;1975 55:1382-1390
9. Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.; Kohsuke Hayamizu MS et al.; Current Therapeutic Research.; Volume 64, Issue 8, September-October 2003, Pages 551-567
10. Aminoguanidine inhibits advanced glycation end products formation on beta2-microglobulin.; FF Hou, J Boyce, GM Chertow, J Kay and WF Owen Jr.; Journal of the American Society of Nephrology, Vol 9, 277-283, Copyright © 1998
11. The effect of extende