Whether or not you have a college degree (BS, Masters, Doctorate etc.) is not relevant. What is more important is that you target a career that keeps you happy and allows you to make good money with relative job security.
For instance, think of the following:
A sandhog (urban miner) in New York City makes around 100K with great benefits and a modified retirement outlook (I've heard they get to retire a little earlier due to their work-related exposure). You don't need a college degree for that.
Plumbers make great money when they have their own local businesses. Many times these individuals charge on a cash basis and make out like bandits (yearly income around 100K-150K, sometimes off the books).
Gardening contractors are also known for their great money and flexible work hours.
If you do go to college, target a career that will bring you both money and security. Consider becoming a doctor, nurse, veterinarian, pharmacist, accountant, engineer and/or a lawyer (stick to corporate law).
Remember, that just as they say there are two things certain in life (death and taxes), so as long as death remains a constant, you will always have sick people knocking at its door. With a world's worth of perpetually sick people, doctors, nurses, and pharmacists will always be in demand and so as long as taxes are an inevitability, accountants will always have a job.
Best of luck,
"1"