There is no hard line between drugs and "natural supplements". Many drugs originate in nature. Many natural compounds sold as supplements in the US are classified as drugs in other countries. For example, yohimbe/yohimbine is an erection drug in some countries.
Here in Sweden agmatine was just classified and pulled off the market. Glucosamine is a drug here and sold at at pharmacies, albeit OTC. Read Yeast Rice is a statin but some idiots think it must be healthy because it's "natural".