It increases the chance of respiratory depression - and since that's already slowed while sleeping, it's a bad mix.
ESFitness - did you ever look into the potentiation and blocking of the C-enzymes that break down its bioavailability when taken orally?
Yep. Except only when taking opiate pills. Used benedryl, tonic water (with quinine... Learned that from one of the few conversations with tom prince), tagamet, & about 20oz of white grapefruit juice all about 30-45mins prior to taking the tabs. Only really did that when using pills, unless i was running low on H. Cant honestly say I noticed much difference. Pills to me would be a waste of time& money since it'd take me 200+mgs of oxycodone or 20+ mg of diluadid to feel anything,& even then the "feeling is sub-par.
Now, after being clean for a lil under a year I've found a combo of 800mg Gabapentin (nerve damage in my hand/arms mostly, but also neck & back issues.. For whatever reason Lyrics doesn't have the same effect. Actually feels worse.), along with 20mg baclophen (mild muscle relaxant. Started using that after reading studies treating alcohol withdrawal/cravings/anxiety successfull), & .10-.15mg clonidine 3x per day works really, really well. It's not an intoxicating feeling, but definitely produces a sort of I can't feel my face physical & mental "high"... All without any feelings of withdrawal. Not hard to get scripts for those meds either. Allows me to fall asleep "naturally",also doesn't interfere with training or make you feel under the influence. I'd assuredly recommend the Gabapentin Baclofen and clonidine combination over a combination of opiates benzos and your typically abused muscle relaxants such as Soma.
I'm surprised by how many people don't take a pro-active approach & spend the time to learn about the drugs/meds they take in order to achieve the desired effect and minimize negative effects.