You won't get 50% absorption transdermally unless
applying to the scrotum. Androgel and such is at 10% max. DMSO probably increases penetration quite a bit
but if you disrupt the dermis too much you'll get irritation and even burns etc, which is why Androgel doesn't contain DMSO and the absorption is low - 10% is probably max for pharma medications before problems arise.
I remember cyclodextrin being popular to compound sublingual and intranasal steroids.
I remember Ronny Tober from Llewellyn's site saying he could make totally painless Test 500. Many don't tolerate ethyl oleate though, which I guess is in the high dosed gear.
did that scrotum thing when i was 20, kind of a burning feeling...
Andractim applied locally around nipples useful to combat gyno as well
i tried RT's T500 at the time, as did many others...wasnt painless at all, was to be avoided at all costs
i put 50% and 40% (of the oils) EO in my T prop 90mg/ml and it still stings 4 out of 5 times
what reduced the coughs and feverish effects was BA at 0.9-1% instead of 2-3 and 40%EO instead of 50%