Getbig Bodybuilding, Figure and Fitness Forums
July 26, 2014, 04:10:59 AM *
Welcome, Guest. Please login or register.

Login with username, password and session length
 
   Home   Help Calendar Login Register  
Pages: [1]   Go Down
  Print  
Author Topic: should you "cycle" creatine?  (Read 1693 times)
tom joad
Getbig IV
****
Posts: 3016

Getbig!


View Profile
« on: December 23, 2006, 11:00:46 PM »

this has probably been covered before . . .  but for you creatine users out there, do you use creatine day-after-day year round or do you take like a 2 or 3 week break from it every couple of months or so?
Report to moderator   Logged
DK II
Getbig V
*****
Posts: 31304


Call me 4 steroids: 571-332-2588 or 571-249-4163


View Profile
« Reply #1 on: December 24, 2006, 04:13:09 AM »

6-8 weeks on, 4-6 weeks off.
Report to moderator   Logged

GET_BIGGER
Getbig IV
****
Gender: Male
Posts: 3032


Peace and good genes be to you


View Profile
« Reply #2 on: December 24, 2006, 02:42:21 PM »

Your body is an adaptable machine.  It gets used to everything.  IMO, you should cycle everything, movements, training days, diet, creatine, you name it......cycle it.  You basically need to shock your body into growth, so you must always keep it guessing........IMO.
Report to moderator   Logged
DK II
Getbig V
*****
Posts: 31304


Call me 4 steroids: 571-332-2588 or 571-249-4163


View Profile
« Reply #3 on: December 25, 2006, 02:50:26 AM »

Your body is an adaptable machine.  It gets used to everything.  IMO, you should cycle everything, movements, training days, diet, creatine, you name it......cycle it.  You basically need to shock your body into growth, so you must always keep it guessing........IMO.

good post, and very true.
Report to moderator   Logged

DK II
Getbig V
*****
Posts: 31304


Call me 4 steroids: 571-332-2588 or 571-249-4163


View Profile
« Reply #4 on: December 28, 2006, 07:09:47 AM »

scientific proof:  Grin Grin Grin


 Down-regulation of the creatine transporter after chronic creatine ingestion:

The creatine transporter (CreaT), responsible for the uptake of creatine into a variety of tissues and cells, was detected in rat skeletal and cardiac muscle, cerebellum, forebrain and kidney. Two polypeptides with an apparent Mr of 70 kDa and 55 kDa were always recognized by both of our specific polyclonal antibodies directed against synthetic peptides of either the NH2- or the COOH-terminus of CreaT, indicating a high degree of homology between the two proteins [51]. In contrast to published data obtained by Northern blot analysis, suggesting a complete absence of CreaT mRNA message in liver, we could clearly detect both CreaT polypeptides also in rat liver and hepatocyte lysates. In support of this, cultured hepatocytes show an endogenous CreaT activity which is antagonized by the creatine analogue, b-guanidino propionic acid (b-GPA), a well known inhibitor of CreaT. Glyco-staining of CreaT, enriched by immuno-affinity chromatography, mainly containing both the 70 and 55 kDa bands, showed strong glycosylation of preferentially the upper 70 kDa polypeptide indicating that the latter is a posttranslationally modified form of the 55 kDa core protein. HeLa cells transfected with rat CreaT cDNA showed an increase in [14C]-creatine uptake, when compared to control cells, that was antagonized by b-GPA. In parallel, an increase in the expression of both the 70 and the 55 kDa polypeptides over endogenous CreaT of controls was noticed on Western blots. Furthermore, we have found that chronic creatine supplementation of rats, at very high dosage, down-regulates in vivo the expression and/or accumulation of the CreaT in skeletal muscle, but not in brain and heart [58]. Although the amounts of creatine taken by athletes, 20 grams / day during a 10 days loading phase and 5 grams as a maintenance dose during the following three months (amounting to approximately 0.1 gram of Cr /kg body weight/ day), is significantly lower than the amounts given in the above experiments to the rats (approximately 0.5 grams /kg body weight /day), the finding made with laboratory animals nevertheless may have consequences with respect to creatine supplementation schedules for humans. In the future, however, detailed studies on humans are needed to optimize the creatine supplementation schedules in use with respect to the observed down-regulation of CreaT expression and/or accumulation in animal experiments. According to most recent results, using "normal" Cr supplementation schedules with humans, CreaT seems also to be down-regulated, especially in combination with exercise (Greenhaff et al. unpublished), but, over the time course of this human trial, creatine transporter function did not seem to become a limiting factor for maintaining normal intracellular creatine levels. Nevertheless, as suggested earlier [86], a one month pause, after three months of continuous creatine supplementation, would still seem to be a reasonable thing to do.
With respect to cardiac pathology, a down-regulation of creatine transporter protein expression has recently been shown in experimental animal models of heart disease, as well as in failing human myocardium [91], indicating that the generally lowered PCr and Cr levels measured in failing hearts are related to down-regulated creatine transporter capacity. Thus, creatine supplementation, by improving cellular energetics, may also turn out to be beneficial for certain heart diseases.


http://icbxw.ethz.ch/creatine/creatine_supplementation.html#English
Report to moderator   Logged

MidniteRambo
Getbig IV
****
Gender: Male
Posts: 1684


1687 confirmed kills and counting


View Profile WWW
« Reply #5 on: December 28, 2006, 08:21:05 AM »

Yes.  I can't improve on the excellent posts above, so I won't.
Report to moderator   Logged
DK II
Getbig V
*****
Posts: 31304


Call me 4 steroids: 571-332-2588 or 571-249-4163


View Profile
« Reply #6 on: December 28, 2006, 12:36:02 PM »

Yes.  I can't improve on the excellent posts above, so I won't.

post whore.  Grin Grin Grin Grin Grin Grin
Report to moderator   Logged

MCWAY
Getbig V
*****
Gender: Male
Posts: 15752


Getbig!


View Profile
« Reply #7 on: December 28, 2006, 06:04:59 PM »

this has probably been covered before . . .  but for you creatine users out there, do you use creatine day-after-day year round or do you take like a 2 or 3 week break from it every couple of months or so?

I use it consistently. My "cycle" if you will, consists of loading for the first week (2 servings of CELL-TECH a day) and maintaining (using one serving of CELL-TECH, postworkout) until the 7-lb jug runs out.
Report to moderator   Logged
Pages: [1]   Go Up
  Print  
 
Jump to:  

Theme created by Egad Community. Powered by MySQL Powered by PHP Powered by SMF 1.1.16 | SMF © 2011, Simple Machines Valid XHTML 1.0! Valid CSS!