Shit, I was wondering about that too. I take Paxil for anxiety, depression, and Trazadone to help me sleep. I was also thinking about getting not taking them while on a cycle, but Im not 100% sure about doing that yet. Ive been on my meds for a good 3 years now, and there have been times when i dont take my paxil. Just about 5 months ago, i didnt take my paxil for 1 month and I felt absolutely fine. My trazadone though is a totally differant story, If i dont take it, i dont sleep, PERIOD. Theres been only 2 times i can think of, where i came home from work and being soo tired, I fell asleep without taking it, but the next day, I wont feel right at all. No "NATURAL STUFF" for me, nope. MELATONIN?? HAHA!!! dont do shit, a whole bottle of melatonin doesnt compare to 10mg of trazadone.