Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus.
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=16754295This landmark paper obviously made an effort to change the widespread misperception that DNP is only dangerous and toxic It points to protective effects in the brain, possible treatments for neurodegenerative diseases like Parkinson's, and even extension of lifespan.
The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsumThis is one of many studies showing that DNP is protective in models where blood flow is interrupted (stroke, heart attack) and then restored. Usually there is a massive release of oxidative stress when this happens. DNP greatly limits this.
Regulation of human male germ cell death by modulators of ATP production.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsumThis study shows that DNP prevents germ cell apoptosis (death). This is the same thing testosterone does. When apoptosis is accelerated, you get all kinds of fertility problems. Looks like DNP may actually help here, depending on the mechanism behind the irregular apoptosis.
Energy requirement for degradation of tumor-associated protein p53.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsump53 is a transcription factor recognized as having anti-cancer effects in cells. There's only good news here with regards to DNP, as DNP has been shown to increase p53 expression. This has been shown both directly in this study and also via AMPK, which DNP clearly activates. AMPK is likely the mechanism through which DNP exerts this anti-cancer effect.
The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15672630This paper showed that pretreatment with DNP significantly reduced the damage from a bruising injury to the spinal cord. Again, this has to do with a reduction in oxidative stress.
