Eventually, even the universe itself will come to an end, as all of the energy in the universe is used up.
Every thing will be at the same temperature, and chemical reactions will cease.
No work can be done. No information will flow. Even intelligence, thought and imagination, will stop.
Nothing will ever change.
By then, perhaps 1000 billion years in the future, there will be nothing left of the universe, but darkness, emptiness, and absolute cold.