Alcohol + Opiates + Benzodiazepines

[be back]

I've already stated how my day went, many times. We all know you've seen it.

Here, instead, practice some self-help

https://www.google.com/amp/s/m.wikihow.com/Deal-with-Obsession-As-an-Autistic-Person%3famp=1

I asked you not to bother...

[NelsonMuntz]

See what I mean Nelson? You pass off your own experiences thinking everybody else's experience must surely be exactly like yours there's no way it could be any different. Haha haha..... it's all a nice little game people like you play with yourselves in order to make yourself feel better. Because if you were a gutter drunk passed out slobbering piece of shit when you were drinking or getting high on whatever you were getting high on, and everybody else must surely have been too and if they're not they're lying!! Right? That's exactly how you think. Pathetic

I think it is more like you are insecure and need to one up everyone here with your tales of utter bullshit.

I don't think you are bad person, but I think you have a serious inferiority complex and try to portray yourself as an expert in everything.

You are that guy where if someone says they just went skydiving for the first time, you can't help yourself and start telling the story of how you went skydiving but did not use a parachute because you are EsFitness of course, the most interesting man on the planet

You make me laugh because you have absolutely no sense of humour, or even ernough sense to figure out people are budting balls on here. No every post is either you bragging or one upping everyone or melting down because you just are too stupid to get the joke.

Oh by the way in reference to me being a gutter drunk, for a guy like you who has been an expert in fucking up it's kind of rich to call others pathetic especially since you have probably been a drain on your family's resources and patience all your life with your jackpots

[ESFitness]

I think it is more like you are insecure and need to one up everyone here with your tales of utter bullshit.

I don't think you are bad person, but I think you have a serious inferiority complex and try to portray yourself as an expert in everything.

You are that guy where if someone says they just went skydiving for the first time, you can't help yourself and start telling the story of how you went skydiving but did not use a parachute because you are EsFitness of course, the most interesting man on the planet

You make me laugh because you have absolutely no sense of humour, or even ernough sense to figure out people are budting balls on here. No every post is either you bragging or one upping everyone or melting down because you just are too stupid to get the joke.

Oh by the way in reference to me being a gutter drunk, for a guy like you who has been an expert in fucking up it's kind of rich to call others pathetic especially since you have probably been a drain on your family's resources and patience all your life with your jackpots

Busting balls? You're a 50yr old man who begs for peoples attention, hoping somebody will finally compliment you on the photoshop's you do of me. Hence posting the same one over and over and over again every thread you can yet getting zero response.

You're a typical AA acolyte. You Preach over and over and over that all addicts and alcoholics are just like you so you can feel better about yourself. Since you have 0 understanding pharmacology or the human body in general and you're not a doctor, then it's surely impossible for anybody else to understand if they're not a doctor either. You rationalize your stupidity.

Seeing how you act deer on this board 50 years old with your little lame photo shops, repeating the same shit over and over and then saying "hey we're just busting your balls", when it should be pretty clear to you by now, most regular people anyways, that I don't bust peoples balls and fuck around like an immature punk, I'm not like you.

Send me all the PM's you want telling me about Your Glory Days of how you were a big tough motorcycle gang member in Canada selling all kinds of drugs and shit and how you and I are a lot of like. Keep telling yourself that try to make yourself feel better anyway you can. Apparently you need it

[Zillotch]

you were a big tough motorcycle gang member in Canada

lol, 'canada' 

[NelsonMuntz]

Busting balls? You're a 50yr old man who begs for peoples attention, hoping somebody will finally compliment you on the photoshop's you do of me. Hence posting the same one over and over and over again every thread you can yet getting zero response.

You're a typical AA acolyte. You Preach over and over and over that all addicts and alcoholics are just like you so you can feel better about yourself. Since you have 0 understanding pharmacology or the human body in general and you're not a doctor, then it's surely impossible for anybody else to understand if they're not a doctor either. You rationalize your stupidity.

Seeing how you act deer on this board 50 years old with your little lame photo shops, repeating the same shit over and over and then saying "hey we're just busting your balls", when it should be pretty clear to you by now, most regular people anyways, that I don't bust peoples balls and fuck around like an immature punk, I'm not like you.

Send me all the PM's you want telling me about Your Glory Days of how you were a big tough motorcycle gang member in Canada selling all kinds of drugs and shit and how you and I are a lot of like. Keep telling yourself that try to make yourself feel better anyway you can. Apparently you need it

\\


lol

[ESFitness]

\\


lol

Or your "Canadian Irish mob" ties.

[be back]

Or your "Canadian Irish mob" ties.

yes, because him claiming to be part of a Canadian Irish Mob isn't really believable.

Unlike all your stories that must be true....

[NelsonMuntz]

Or your "Canadian Irish mob" ties.

that's nice,

you forgot the yakuza, pablo escobar and Dnald trump

[ESFitness]

that's nice,

you forgot the yakuza, pablo escobar and Dnald trump

Are you trying to get me to post the PMs? Found out after I posted whitewidows pms to me asking to help him sell pain pills that that's a "bannable" offense. Convenient.

I can just take a screen shot and textem to somebody. Like I'm gonna make it up. Esp since I didn't know you're in Canada or that you're Irish. Don't give a fuck either. I do know you're a poser and desperate for acceptance.

[be back]

Are you trying to get me to post the PMs? Found out after I posted whitewidows pms to me asking to help him sell pain pills that that's a "bannable" offense. Convenient.

I can just take a screen shot and textem to somebody. Like I'm gonna make it up. Esp since I didn't know you're in Canada or that you're Irish. Don't give a fuck either. I do know you're a poser and desperate for acceptance.

pot , kettle, black.....

You are even worse than dj181 in the lack of self esteem department.

Your constant brag ado posting style of reeks of insecurity.

[ESFitness]

that's nice,

you forgot the yakuza, pablo escobar and Dnald trump

Ahh.. I found the PM. Talking about your "ties to the Irish mob in Montreal."

LoL

[be back]

Ahh.. I found the PM. Talking about your "ties to the Irish mob in Montreal."

LoL

thats more believable that you training Linda Lee and Fabio....

[Taffin]

Had to post this due to the "up the dose" quote 


"Natural painkiller nasal spray could replace addictive opioids, trial indicates

Risk of overdose could be far lower, say researchers, as fundraising for human clinical trials begins

A nasal spray that delivers a natural painkiller to the brain could transform the lives of patients by replacing the dangerous and addictive prescription opioids that have wreaked havoc in the US and claimed the lives of thousands of people.

Scientists at University College London found they could alleviate pain in animals with a nasal spray that delivered millions of soluble nanoparticles filled with a natural opioid directly into the brain. In lab tests, the animals showed no signs of becoming tolerant to the compound’s pain-relieving effects, meaning the risk of overdose should be far lower.

The researchers are now raising funds for the first clinical trial in humans to assess the spray’s safety. They will start with healthy volunteers who will receive the nasal spray to see if it helps them endure the pain of immersing one of their arms in ice-cold water.

“If people don’t develop tolerance, you don’t have them always having to up the dose. And if they don’t have to up the dose, they won’t get closer and closer to overdose,” said Ijeoma Uchegbu, a professor of pharmaceutical nanoscience who is leading the research through Nanomerics, a UCL startup

Uchegbu believes the approach is promising because natural opioids seem to work differently in the body to synthetic opioids, such as oxycodone and fentanyl, which are commonly used for moderate to severe pain. While the body quickly becomes tolerant to synthetic opioids, meaning patients need more over time to get the same pain relief, that does not seem to happen with natural opioids.

Scientists have long seen the potential for using natural opioids as painkillers, but have been thwarted by both the compounds and the brain. Inject natural opioids into the bloodstream and they are swiftly broken down in the liver. What is left faces another hurdle in crossing the barrier to the brain that is effective at filtering out the compounds.

Writing in the Journal of Controlled Release, Uchegbu and her team showed they could deliver pain-relieving levels of a natural opioid called enkephalin straight to rats’ brains by encapsulating the chemical in soluble polymer nanoparticles. The tiny capsules provided just enough protection for the opioid to reach parts of the brain where it could block pain perception. Once the particles had dissolved, the breakdown products were excreted from the body.

Uchegbu believes the approach is promising because natural opioids seem to work differently in the body to synthetic opioids, such as oxycodone and fentanyl, which are commonly used for moderate to severe pain. While the body quickly becomes tolerant to synthetic opioids, meaning patients need more over time to get the same pain relief, that does not seem to happen with natural opioids.

Scientists have long seen the potential for using natural opioids as painkillers, but have been thwarted by both the compounds and the brain. Inject natural opioids into the bloodstream and they are swiftly broken down in the liver. What is left faces another hurdle in crossing the barrier to the brain that is effective at filtering out the compounds.

Writing in the Journal of Controlled Release, Uchegbu and her team showed they could deliver pain-relieving levels of a natural opioid called enkephalin straight to rats’ brains by encapsulating the chemical in soluble polymer nanoparticles. The tiny capsules provided just enough protection for the opioid to reach parts of the brain where it could block pain perception. Once the particles had dissolved, the breakdown products were excreted from the body."

https://www.theguardian.com/us-news/2018/feb/01/natural-painkiller-nasal-spray-could-replace-addictive-opioids-trial-indicates

[ESFitness]

Had to post this due to the "up the dose" quote 


"Natural painkiller nasal spray could replace addictive opioids, trial indicates

Risk of overdose could be far lower, say researchers, as fundraising for human clinical trials begins

A nasal spray that delivers a natural painkiller to the brain could transform the lives of patients by replacing the dangerous and addictive prescription opioids that have wreaked havoc in the US and claimed the lives of thousands of people.

Scientists at University College London found they could alleviate pain in animals with a nasal spray that delivered millions of soluble nanoparticles filled with a natural opioid directly into the brain. In lab tests, the animals showed no signs of becoming tolerant to the compound’s pain-relieving effects, meaning the risk of overdose should be far lower.

The researchers are now raising funds for the first clinical trial in humans to assess the spray’s safety. They will start with healthy volunteers who will receive the nasal spray to see if it helps them endure the pain of immersing one of their arms in ice-cold water.

“If people don’t develop tolerance, you don’t have them always having to up the dose. And if they don’t have to up the dose, they won’t get closer and closer to overdose,” said Ijeoma Uchegbu, a professor of pharmaceutical nanoscience who is leading the research through Nanomerics, a UCL startup

Uchegbu believes the approach is promising because natural opioids seem to work differently in the body to synthetic opioids, such as oxycodone and fentanyl, which are commonly used for moderate to severe pain. While the body quickly becomes tolerant to synthetic opioids, meaning patients need more over time to get the same pain relief, that does not seem to happen with natural opioids.

Scientists have long seen the potential for using natural opioids as painkillers, but have been thwarted by both the compounds and the brain. Inject natural opioids into the bloodstream and they are swiftly broken down in the liver. What is left faces another hurdle in crossing the barrier to the brain that is effective at filtering out the compounds.

Writing in the Journal of Controlled Release, Uchegbu and her team showed they could deliver pain-relieving levels of a natural opioid called enkephalin straight to rats’ brains by encapsulating the chemical in soluble polymer nanoparticles. The tiny capsules provided just enough protection for the opioid to reach parts of the brain where it could block pain perception. Once the particles had dissolved, the breakdown products were excreted from the body.

Uchegbu believes the approach is promising because natural opioids seem to work differently in the body to synthetic opioids, such as oxycodone and fentanyl, which are commonly used for moderate to severe pain. While the body quickly becomes tolerant to synthetic opioids, meaning patients need more over time to get the same pain relief, that does not seem to happen with natural opioids.

Scientists have long seen the potential for using natural opioids as painkillers, but have been thwarted by both the compounds and the brain. Inject natural opioids into the bloodstream and they are swiftly broken down in the liver. What is left faces another hurdle in crossing the barrier to the brain that is effective at filtering out the compounds.

Writing in the Journal of Controlled Release, Uchegbu and her team showed they could deliver pain-relieving levels of a natural opioid called enkephalin straight to rats’ brains by encapsulating the chemical in soluble polymer nanoparticles. The tiny capsules provided just enough protection for the opioid to reach parts of the brain where it could block pain perception. Once the particles had dissolved, the breakdown products were excreted from the body."

https://www.theguardian.com/us-news/2018/feb/01/natural-painkiller-nasal-spray-could-replace-addictive-opioids-trial-indicates

Skimmed this twice and still haven't found what the actual chemical/drug is

[be back]

Skimmed this twice and still haven't found what the actual chemical/drug is

read it properly, its there...

[Taffin]

Skimmed this twice and still haven't found what the actual chemical/drug is

It's in the last para - Enkephalin - ever heard of if?

https://pubchem.ncbi.nlm.nih.gov/compound/leucine_enkephalin#section=Top

[be back]

It's in the last para - Enkephalin - ever heard of if?

https://pubchem.ncbi.nlm.nih.gov/compound/leucine_enkephalin#section=Top

he probably invented it...

[chess315]

lol a kilo a month - this is physically impossible you would be dead on much smaller dosages than that.

I didn't say I did a kilo a month went through a kilo that's 10,000 doses give or take I probably never took 10grams a month. I would say a gram could potentially kill hospitalis a person

[Van_Bilderass]

Anyone here tried Semax or Selank?

[be back]

Anyone here tried Semax or Selank?

I used a gram a day of each everyday from 94-2002, I shit out all my internal organs but Im not stupid, I always shit through a tennis racquet which allows me to re-insert them later, I can operate on myself because I have a library which contains a full selection of medical books.
I always have three nurses on standby at all times, I insist they weigh no more than 96.5lbs..

PS I was in prison you know,,,

[Van_Bilderass]

I used a gram a day of each everyday from 94-2002, I shit out all my internal organs but Im not stupid, I always shit through a tennis racquet which allows me to re-insert them later, I can operate on myself because I have a library which contains a full selection of medical books.
I always have three nurses on standby at all times, I insist they weigh no more than 96.5lbs..

PS I was in prison you know,,,

But seriously, non-addictive anti-anxiety substances would be highly useful. A lot of interesting stuff available in the US and UK for example, stuff I can't get unless I try to import 

[Taffin]

Anyone here tried Semax or Selank?

No, and in fact I'd never heard of them until now... but it's made for some interesting Googling thanks - particularly Selank.... Thanks Doc 

[Zillotch]

non-addictive anti-anxiety substances would be highly useful.

there is only one... p o t

[Nether Animal]

i was on something called tianeptine most of last year. novel antidepressant that hits opiate receptors felt great on it and not HIGH, just a clear focus and sense of well being just short of euphoria. but the prices have skyrocketed due to chinese import restrictions,

[Taffin]

i was on something called tianeptine most of last year. novel antidepressant that hits opiate receptors felt great on it and not HIGH, just a clear focus and sense of well being just short of euphoria. but the prices have skyrocketed due to chinese import restrictions,

Interesting.  Anything that alters serotonin and its buddies suggests a need to taper off when you're done with them.  I'm not familiar with the other pathway mentioned below, so how was coming off this stuff...?

"In terms of chemical classification, tianeptine is a tricyclic antidepressant (TCA). However, its pharmacology and effects vary from those of typical antidepressant and anxiolytics[3], mainly in the fact that it is not thought to act immediately through the regulation of monoaminergic neurotransmitters (such as serotonin, dopamine, and noradrenaline.) Rather, tianeptine is theorized to act upon glutamate and glutamatergic mechanisms, causing the brain to adapt more readily to stress and depression.[4]"

https://psychonautwiki.org/wiki/Tianeptine