Syracuse- although pretty much any city in the upstate region of NYS now looks like shit. I was in Rochester a year ago and man that place has gotten depressed. And that was one of the bright spots in NY for many years.
The reason I said Schenectady is because of the GE plant and yes it is a shit hole.
Not too familiar with western New York but I do know the capital region and Albany is pretty much a shithole as well although there are some nice areas outside of it.