Something can also be said about androgen receptor polymorphism. Each individual does not possess the exact same androgen receptors
This is a crucial point regarding testosterone and, broadly speaking, androgen sensitivity.
The gene encoding androgen receptors is polymorphic. Polymorphims in genetics means that several variations of a specific DNA sequence can occur among different individuals or populations.
Each individual will produce a slightly different kind of androgen receptors depending on it's codon repeats.
A codon is a DNA sequence of 3 nucleotides.
Nucleotides are molecules composed of a sugar, a phosphate and, most importantly, a base ( Adenine, Thymine, Cytosine, Guanine - abbreviated A,T,C,G)
Now here's the thing, the genetic sequence coding for androgen receptors is composed of C-A-G codon repeats. ( Cytosine - Adenine - Guanine )
In normal people, the CAG repeats can range from 6 to 39 ( in other words, this code can be repeated 6 times up to 39 times to produce an androgen receptor.)
My point is that there are two kinds of people in this world :
• Those with short CAG repeats ( up to 23 repeats.) They are the most sensitive to androgen action, and consequently are typically more masculine, both in terms of appearance and personality.
• Those with long repeats ( from 23 to 39 ). Those folks are typically less androgen sensitive. Estrogen production also tends to be higher in men with long CAG repeats....
There were 2,5 billion people in the world in 1950. Today, where are ~ 8 billion.
A wider gene pool, higher standards of living and negative natural selection ( the "weak" survive and reproduce more often) could partially explain why men are supposedly becoming weaker