Glucose Taking a Beating From Weights

[AbrahamG]

I did both moderna and pfizer and have been double dipping on boosters. i am up to 14 right now and unless someone cuts me off or stops me I will keep getting them until I can't.

I've had more than that.  The first two years, I used my fake ID (the one that I use to vote multiple times) to double dip.  Next month will be my 20th shot or 18th boost. 

[Zillotch]

-

u r quite the blowtard.

can any of your ancestry b traced back to india, at all?

[Methyl m1ke]

ya my readings are also 2 points higher on waking

i can keep my A!C in the 6.5 range which Im happy with considering it was 12.5 4 months ago
When I train super heavy and do a reading say an hour after its rocket high--as high as 11
when i do lighter training with cardio it can shootu p to 8 but i can get it back into the 6s pretty quick
when i do only cardio its very good and i have had it down to 5.5

zero doubt heavy training shoots it way up

You get a high reading after working out because your body has been mobilizing glucose stores to supply you with energy. Its not anything to be concerned about.

[Necrosis]

u r quite the blowtard.

can any of your ancestry b traced back to india, at all?

I do have a bindi

[BigRo]

I've had more than that.  The first two years, I used my fake ID (the one that I use to vote multiple times) to double dip.  Next month will be my 20th shot or 18th boost.

Mind blowing retardation. Fucking hell how scared are you of a flu?

[BigRo]

I did both moderna and pfizer and have been double dipping on boosters. i am up to 14 right now and unless someone cuts me off or stops me I will keep getting them until I can't.

True to your name retard.

[IroNat]

I've had more than that.  The first two years, I used my fake ID (the one that I use to vote multiple times) to double dip.  Next month will be my 20th shot or 18th boost. 

Quoted for archives.

[Necrosis]

Mind blowing retardation. Fucking hell how scared are you of a flu?

Are you autistic? this feels like projection.

We are joking obviously ffs. Ya man he used his fake id which he used to vote fraudulently to horde vaccine shots in his anus.

Just in case you still don't understand whats going on here, I have one shot as I had to for work.

[Krankenstein]

I am just trying to be helpful here, I am a doc, while no endocrinologist this stuff and particularly neuropsychiatric stuff is my bread and butter (cause I am insane and work out ). I say that just so I dont have to be posting 20 pubmed links as I am lazy and currently doing a teaching rotation 

It can elevate cortisol quite acutely, it's well documented. So much so that it can cause impaired memory and learning. Which is likely related to cortisols effect on the hippocampus.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8957269/

Weight lifting is a hormetic stressor- technically damaging (so are fruits and veggies actually) but the response of the body is beneficial, only if and thats a big if, the allostatic load of the system can get back to allostasis. Heavy weights increase neural drive and recruitment and a higher HPA response because of the intensity.

His system with type 2 has systemic inflammation- its the likely cause of type 2 and most diseases- basically resistance causes oxidative stress and myokine/cytokine responses. The liver struggles to handle the load as well and that leads to all kinds of pro-inflammatory mediators being released into the system. Over time it worsens and beta cells begin to fail from oxidation amongst other things and you get type 2.
https://pubmed.ncbi.nlm.nih.gov/22252015/

you generally see higher crp, tnfa and nuclear factor kappa beta activation in type 2.

You are correct on the supplement, I was just fucking about.

What is likely going on here is he is lifting heavy, causing stress to the system which is already in overdrive, cortisol is released to dampen things, he has insulin resistance which cortisol is exacerbating leading to more insulin release then needed hence the fatigue and feeling shitty. There is likely a counter release of glucagon which does some odd shit to the body as well.

Oh, so you wanna get into a pubmed posting war, huh?   

I can totally agree with the acute spike of cortisol, but again so many make cortisol out to be worse than agent smith.  Yes, the heavy lifting can elevate it because the HPA axis thinks we’re trying to not get Clegged. We can agree that in a healthy system, that’s adaptive: cortisol mobilizes glucose and fats, then insulin cleans up the mess.

For Josh's type 2, the “cleanup crew” is on strike. What is interesting (and confusing to me) is that he is using metformin and berberine and shouldn't be getting this kind of spiking (safe assumption).  I will admit that I am not highly knowledgable about the drug side of things. Could it be that with the low carb and then meds, his pancreas is still trying to pump out insulin, while glucagon is acting like DJ181818181??

HArd to argue that resistance training is not still the best way to fix the mess—it as it will improve insulin sensitivity and "lowers" inflammation—but in the short term the hormonal rollercoaster is a bit rougher when the system’s already overloaded.

[BigRo]

Are you autistic? this feels like projection.

We are joking obviously ffs. Ya man he used his fake id which he used to vote fraudulently to horde vaccine shots in his anus.

Just in case you still don't understand whats going on here, I have one shot as I had to for work.

Must be then.

[Krankenstein]

Berberine has far better evidence and actually works for other things. However, he is already on an AMPK activator so the overlap would be moot for the most part.

Shit, acetic acid has better evidence then those items.

Also, have you heard of the dawn phenomenon? even normal cortisol release can exacerbate glucose levels and cause normal gluconeogenesis in the liver to be problematic.

Wouldn't the berberine + metformin control dawn phenomenon by slowing down the liver’s “sugar dump.” Obviously the dose of the two, carb intake, and timing matter, but thats why I was suggesting tracking glucose to make sure he's not fixing the dawn rise by creating problems later.  Again, When it comes to pharms...thats not my forte'.

[Krankenstein]

" oatmeal with protein powder and 2 eggs
protein shake
chicken andbeef on brown rice and veggies (EDO)
protein bar
chicken breast 2 pieces of carbonaut seeded bread
protein shake
50 grams protein of ground beef sometimes with a salad
protein bar
4 whole eggs 3 whites cheese omelette
maybe another protein shake

l carnitine preworkout
electrolytes/creatine during workout
15 grams creatine spread out"

>
What's in the protein shakes and bars?  Any carbs?
Finely powdered whey can spike glucose levels and thus insulin levels.
Excess protein also gets converted to glucose.
No need to eat 300+ g of protein a day.

Type 2 is an indication of insulin resistance.

Hope you took the time to watch the video I posted above.

I think the whey protein thing has to be taken in context....when comparing fast-absorbing whey isolate or hydrolysate with casein, yes...whey will raise BS.  I don't think there is any product called 'coarse' whey protein.  Where did you see this with "fine powdered"?

Also, to clarify...protein doesn't get converted to glucose.  SOME amino acids are gluconeogenic...while others are ketogenic.

[Krankenstein]

I did both moderna and pfizer and have been double dipping on boosters. i am up to 14 right now and unless someone cuts me off or stops me I will keep getting them until I can't.

Rookie numbers... 

[Necrosis]

Wouldn't the berberine + metformin control dawn phenomenon by slowing down the liver’s “sugar dump.” Obviously the dose of the two, carb intake, and timing matter, but thats why I was suggesting tracking glucose to make sure he's not fixing the dawn rise by creating problems later.  Again, When it comes to pharms...thats not my forte'.

It should but it would depend on the severity of the type 2 and the normal cortisol spike in the am that blunts insulins action. Metformin mostly acts through ampk and so does berberine, there are other mechanisms but hitting other pathways may be the best way to combat it.

I don't know if its the case but I think acetic acid (apple cider vinegar) before bed might help as well.

If he could lose weight the dawn phenomenon shouldn't be an issue mostly.

[Krankenstein]

It should but it would depend on the severity of the type 2 and the normal cortisol spike in the am that blunts insulins action. Metformin mostly acts through ampk and so does berberine, there are other mechanisms but hitting other pathways may be the best way to combat it.

I don't know if its the case but I think acetic acid (apple cider vinegar) before bed might help as well.

If he could lose weight the dawn phenomenon shouldn't be an issue mostly.

Side question, not to derail Josh's thins, but what are your thoughts on a small carb meal before bed.  Been reading more on producing tryptophan and melatonin before bed helps.  I am not a big fan on exogenous consumption of melatonin.  Currently I do about 150gm of cottage cheese with a slice of bread and a blend of frozen tart cherry mixed with some magnesium, GABA, and l-theonine

[Van_Bilderass]

Some stuff on the CNS fatigue, reference links in the article:

Myth 1: The higher the exercise intensity, the more CNS fatigue you induce
CNS fatigue is commonly said to occur from exercise with large neural demands, namely high intensity exercise. So the theory is that low reps induce more CNS fatigue than high reps. It sounds very plausible. The higher the training intensity, the CNS activation is required, the more fatigued the CNS gets, right?

Wrong. It’s completely the other way around. Low intensity, high duration exercise causes far more central fatigue than short, high intensity exercise [2, 3, 4].

CNS fatigue is readily observed after endurance exercise, like marathons, but scientists often really have to go out of their way to reliably induce central nervous system fatigue with strength training.

Barnes et al. (2017) directly studied the claim that deadlifts cause more CNS fatigue than squats. They had trained men perform 8 sets of 2 reps at 95% of 1RM with 5 minutes of rest in between sets in the squat and deadlift on separate occasions. These heavy-duty powerlifting workouts indeed resulted in central fatigue, though not all that much: a 5-10% reduction in central neural output. In spite of the higher weights used, greater amount of musculature involved in and greater total work performed during the deadlifts, the deadlifts did not result in more central fatigue than the squats. There was also no significant difference in testosterone or cortisol production.

https://mennohenselmans.com/cns-fatigue/#:~:text=In%20any%20case%2C%20high%20activation,CNS%20fatigue%20than%20higher%20reps.

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[Van_Bilderass]

Been reading more on producing tryptophan and melatonin before bed helps.  I am not a big fan on exogenous consumption of melatonin. 

I am currently taking an extremely high dose of melatonin for theoretical benefits, for example might help protect my pancreas since I have active pancreatitis at this minute. I'm taking 30mg, dosage based on nothing much, have to look up what kind of dosages are proposed. That Leo Longevity madman said he had found a 400mg Melatonin suppository on Amazon he was going to try.

Melatonin has a protective and restorative role in acute pancreatitis due to its potent antioxidant properties and its ability to activate antioxidant enzymes, suppress pro-inflammatory cytokines, and reduce tissue damage and necrosis.

Melatonin has a protective and restorative role in acute pancreatitis due to its potent antioxidant properties and its ability to activate antioxidant enzymes, suppress pro-inflammatory cytokines, and reduce tissue damage and necrosis.

Same kind of data wrt to putative liver and kidney protection can be found.

My post is way O/T too but I don't think especially your useful post derail anything, anything about related topics can only help overall understanding... IMHO at least.

Since insulin sensitivity is discussed, taking melatonin in the daytime cause acute insulin resistance which is interesting.

Some "gurus" have recommended the following when not getting optimal sleep and still wanting to perform optimally:

First night after having suboptimal sleep or knowing you won't get enough that night:
10mg Melatonin at night, 10 grams of creatine in the morning. 2nd night double initial dosage of both, 3rd day add another 10mg Mela and 10g creatine in the morning. I would maybe add tyrosine with the creatine. This is just for conversation, no recommendation

[loco]

I wore a Continuous Glucose Monitor (CGM) for a year.  I was on a strict carnivore diet, still am.

My glucose was always slightly elevated upon weaking up in the morning, dawn phenomenon.

When I ate my steak or ground beef, my glucose stayed the same or even dropped slightly some times.

When I walked on the treadmill with an incline, my glucose stayed the same.

When I lifted weights, my glucose jumped 30-40 mg/dL.  This is normal.  Your body knows you'll need more quick burning energy when lifting/sprinting.

[CalorieKing]

I wore a Continuous Glucose Monitor (CGM) for a year.  I was on a strict carnivore diet, still am.

My glucose was always slightly elevated upon weaking up in the morning, dawn phenomenon.

When I ate my steak or ground beef, my glucose stayed the same or even drop slightly some times.

When I walked on the treadmill with an incline, my glucose stayed the same.

When I lifted weights, my glucose jumped 30-40 mg/dL.  This is normal.  Your body knows you'll need more quick burning energy when lifting/sprinting.

good post thanks for info

[Necrosis]

Oh, so you wanna get into a pubmed posting war, huh?   

I can totally agree with the acute spike of cortisol, but again so many make cortisol out to be worse than agent smith.  Yes, the heavy lifting can elevate it because the HPA axis thinks we’re trying to not get Clegged. We can agree that in a healthy system, that’s adaptive: cortisol mobilizes glucose and fats, then insulin cleans up the mess.

For Josh's type 2, the “cleanup crew” is on strike. What is interesting (and confusing to me) is that he is using metformin and berberine and shouldn't be getting this kind of spiking (safe assumption).  I will admit that I am not highly knowledgable about the drug side of things. Could it be that with the low carb and then meds, his pancreas is still trying to pump out insulin, while glucagon is acting like DJ181818181??

HArd to argue that resistance training is not still the best way to fix the mess—it as it will improve insulin sensitivity and "lowers" inflammation—but in the short term the hormonal rollercoaster is a bit rougher when the system’s already overloaded.

ya the pubmed wars are tiring lol, especially since I dont have any of the data handy, i'm relying on trust me bro

Resistence training does appear to be the best solution, I recall a study done to ascertain this, cardio had the best immediate effects which I think is expected but for HBA1C resistance training proved superior. I would suspect if you combine then in high rep, superset training- like agonist and antagonist he might not see a spike at all.

[Necrosis]

Side question, not to derail Josh's thins, but what are your thoughts on a small carb meal before bed.  Been reading more on producing tryptophan and melatonin before bed helps.  I am not a big fan on exogenous consumption of melatonin.  Currently I do about 150gm of cottage cheese with a slice of bread and a blend of frozen tart cherry mixed with some magnesium, GABA, and l-theonine

I don't see any downside if you are healthy. The insulin will suppress cortisol to a point so thats a good thing. I am unsure if there is any studies on the matter. I can have a look

I am a big fan of glycine prior to bed, it appears to increase delta wave sleep, appears to lower core temp which is good, lowers cortisol.

I also agree with your thoughts on cortisol- its absolutely required and healthy, its the context that matters and type 2- especially with a HBA1C of 12 at one point is severe metabolic damage so all his shit is going to be out of wack for a long time, unfortunately. 12 is really god damn high and his blood must of been sludge.

Your sleep regimen is sound and researched, i would probably do magnesium threonate if you arent

[Necrosis]

I wore a Continuous Glucose Monitor (CGM) for a year.  I was on a strict carnivore diet, still am.

My glucose was always slightly elevated upon weaking up in the morning, dawn phenomenon.

When I ate my steak or ground beef, my glucose stayed the same or even drop slightly some times.

When I walked on the treadmill with an incline, my glucose stayed the same.

When I lifted weights, my glucose jumped 30-40 mg/dL.  This is normal.  Your body knows you'll need more quick burning energy when lifting/sprinting.

Yes but are you still in range and do you have type 2 diabetes? It should not go out of range in metabolically healthy folks. You are also likely inducing peripheral insulin resistance eating the way you are but it won't matter as you don't eat carbs. I think keto is fantastic for so many things.

[Necrosis]

Some stuff on the CNS fatigue, reference links in the article:

I will have a look at the studies they are citing. Thanks and how dare you

[Humble Narcissist]

True to your name retard.

No shit.

[loco]

Yes but are you still in range and do you have type 2 diabetes? It should not go out of range in metabolically healthy folks. You are also likely inducing peripheral insulin resistance eating the way you are but it won't matter as you don't eat carbs. I think keto is fantastic for so many things.

No type 2 diabetes.  My fasting glucose, fasting insulin, A1C, and HOMA-IR are all normal to optimal.