i dont use spiro anymore. i dont think it works. plus, if you use something like emu oil to increase absorption you will increase systemic absorption as well leading to some really nasty side effects.
Spiro even when used with emu oil will have a tough time getting systemic. It will absorb through the epidermis and spread surface wise throughout. If a little does make it through to the dermis there wont be much left of it.
As far as having systemic effects, as long as you are on steroids it will do nothing to feminize u or anything like that. I was discussing this with someone and he pretty much said its perfect to use topically as hair loss preventative, as long as u are on androgens aka gear. It will completely negate any anti-androgenic effects of spiro systemically, yet spiro is still allowed to work topically on the scalp.