Ronnie is a mutant. He's a super-strong hyper-responder. But a Mensa candidate he is not. He only knew one way to train--100% all out, balls to the wall.
Coleman's 2003 condition was a level never reached before, and possibly never again, unless someone else comes along willing to punish their body enough to take it to the next level, and pay the price that Ronnie is paying now.