At the very first sign of osteoarthritis in my knees at age 47 I made the decision to go from an Arnoldesque 244 lbs to 167 lb. Bruce Lee physique. I can still remember the doctor shooting my knees up that day with cortisone, telling me eventually I'm looking at total knee replacements. I asked if there was any other way. He told me to a.) Lose a ton of weight and b.) Work on strengthening the calves, hamstrings and glutes in addition to the quads, and I just might get out of the surgery. So I began a super strict diet and started doing lots and lots of cardio on the exercise bike. (Running was out of the question due to the knee pain). I kept lifting and really hit the core hard. Not only did the knee pain all but disappear but I also was relieved of some sciatic nerve pain. Psychologically it was difficult at first to deal with the loss of size, but another phenomenon developed whereby when I remove my shirt (on the beach for example) the world seems to stop and stare at my chiseled, defined Bruce Lee physique. The abs, intercostals, serratus, are all carved out of granite. The sexual attention I get from the ladies is one hundred fold what it was with my Arnold physique. I am now in my late 50s now and look to be in my 30s with little to no knee pain.